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. 2023 Mar 20;36(3):342-346.
doi: 10.1021/acs.chemrestox.2c00391. Epub 2023 Feb 16.

Carbonyl Emissions and Heating Temperatures across 75 Nominally Identical Electronic Nicotine Delivery System Products: Do Manufacturing Variations Drive Pulmonary Toxicant Exposure?

Soha Talih  1   2 , Rola Salman  1   2 , Nareg Karaoghlanian  1   2 , Ahmad El-Hellani  3 , Alan Shihadeh  1   2
Affiliations

Carbonyl Emissions and Heating Temperatures across 75 Nominally Identical Electronic Nicotine Delivery System Products: Do Manufacturing Variations Drive Pulmonary Toxicant Exposure?

Soha Talih et al. Chem Res Toxicol. .

Abstract

Studies of factors that impact electronic nicotine delivery systems (ENDSs) carbonyl compound (CC) emissions have been hampered by wide within-condition variability. In this study, we examined whether this variability may be related to heating coil temperature variations stemming from manufacturing differences. We determined the mean peak temperature rise (ΔTmax) and CC emissions from 75 Subox ENDSs powered at 30 W. We found that ΔTmax and CC emissions varied widely, with greater ΔTmax resulting in exponentially higher CC emissions. Also, 12% of atomizers accounted for 85% of total formaldehyde emissions. These findings suggest that major reductions in toxicant exposure might be achieved through regulations focusing on limiting coil temperature.

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Conflict of interest statement

The authors declare the following competing financial interest(s): Dr. Shihadeh is named on a patent for a device that measures the puffing behavior of electronic cigarette users and serves as a scientific consultant in litigation against the tobacco industry.

Figures

Figure 1
Figure 1
Formaldehyde yields vs ΔTmax (N = 75); log scale. An exponential model was used to fit formaldehyde yield as a function of ΔTmax.
Figure 2
Figure 2
Cumulative formaldehyde emissions versus percentile of samples.
See this image and copyright information in PMC

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