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Review
. 2023 Feb 15;37(2):202-207.
doi: 10.7507/1002-1892.202210019.

[Research progress of matrix stiffness in regulating endothelial cell sprouting]

[Article in Chinese]
Qiyu Chen  1 , Wen Wang  1   2 , Changyong Yuan  1   3 , Penglai Wang  1   3
Affiliations
Review

[Research progress of matrix stiffness in regulating endothelial cell sprouting]

[Article in Chinese]
Qiyu Chen et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To review the research progress on the role and mechanism of matrix stiffness in regulating endothelial cell sprouting.

Methods: The related literature at home and abroad in recent years was extensively reviewed, and the behaviors of matrix stiffness related endothelial cell sprouting in different cell cultivation conditions were analyzed, and the specific molecular mechanism of matrix stiffness regulating related signal pathways in endothelial cell sprouting was elaborated.

Results: In two-dimensional cell cultivation condition, increase of matrix stiffness stimulates endothelial cell sprouting within a certain range. However, in three-dimensional cell cultivation condition, the detailed function of matrix stiffness in regulating endothelial cell sprouting and angiogenesis are still unclear. At present, the research of the related molecular mechanism mainly focuses on YAP/TAZ, and roles of its upstream and downstream signal molecules. Matrix stiffness can regulate endothelial cell sprouting by activating or inhibiting signal pathways to participate in vascularization.

Conclusion: Matrix stiffness plays a vital role in regulating endothelial cell sprouting, but its specific role and molecular mechanism in different environments remain ambiguous and need further study.

目的: 综述基质刚度对内皮细胞出芽的作用与机制研究进展。.

方法: 广泛查阅近年来国内外相关文献，分析不同细胞培养条件下，基质刚度对内皮细胞出芽的作用，详细阐述基质刚度在内皮细胞出芽中调控相关信号通路的分子机制。.

结果: 二维细胞培养条件下，在一定范围内提高基质刚度能促进内皮细胞出芽。然而，三维细胞培养条件下，基质刚度对内皮细胞出芽及成血管的作用尚不明确。现阶段相关分子机制研究主要聚焦于YAP/TAZ及其上、下游信号分子的作用，基质刚度可通过激活或抑制信号通路调控内皮细胞出芽来参与血管生成。.

结论: 基质刚度对内皮细胞出芽的调控起重要作用，但不同环境下的具体作用及分子机制尚不明确，需进一步研究。.

Keywords: Matrix stiffness; angiogenesis; endothelial cells; mechanism; sprouting; tissue engineering.

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Conflict of interest statement

利益冲突 在文章撰写过程中不存在利益冲突；经费支持没有影响文章观点及其报道

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