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. 2023 Jan;65(1):e15487.
doi: 10.1111/ped.15487.

Neurocognitive outcomes of children with osteosarcoma treated with methotrexate

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Neurocognitive outcomes of children with osteosarcoma treated with methotrexate

Haruko Shima et al. Pediatr Int. 2023 Jan.
No abstract available

Keywords: children; late effects; methotrexate; neurocognitive outcomes; osteosarcoma.

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References

REFERENCES

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    1. Edelmann MN, Daryani VM, Bishop MW, Liu W, Brinkman TM, Stewart CF, et al. Neurocognitive and patient-reported outcomes in adult survivors of childhood osteosarcoma. JAMA Oncol. 2016;2:201-8.
    1. Feng S, Cen J, Huang Y, Shen H, Yao L, Wang Y, et al. Matrix metalloproteinase-2 and -9 secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight junction proteins. PLoS One. 2011;6:e20599.
    1. Jacola LM, Conklin HM, Krull KR, Pei D, Cheng C, Reddick WE, et al. The impact of intensified CNS-directed therapy on neurocognitive outcomes in survivors of childhood acute lymphoblastic leukemia treated without cranial irradiation. J Clin Oncol. 2022;40(36):4218-27.

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