Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis

doi:10.1007/s12640-022-00632-1

Review

. 2023 Jun;41(3):288-309.

doi: 10.1007/s12640-022-00632-1. Epub 2023 Feb 17.

Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis

Lucas Matheus Gonçalves de Oliveira^#¹, Rodrigo Barreto Carreira^#¹, Juciele Valeria Ribeiro de Oliveira¹, Ravena Pereira do Nascimento¹, Cleide Dos Santos Souza², Emiliano Trias³, Victor Diogenes Amaral da Silva⁴, Silvia Lima Costa⁵

Affiliations

¹ Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil.
² Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
³ Institut Pasteur de Montevideo, Montevideo, Uruguay.
⁴ Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. vdsilva@ufba.br.
⁵ Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. costasl@ufba.br.

^# Contributed equally.

PMID: 36800114
DOI: 10.1007/s12640-022-00632-1

Review

Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis

Lucas Matheus Gonçalves de Oliveira et al. Neurotox Res. 2023 Jun.

. 2023 Jun;41(3):288-309.

doi: 10.1007/s12640-022-00632-1. Epub 2023 Feb 17.

Authors

Affiliations

¹ Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil.
² Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
³ Institut Pasteur de Montevideo, Montevideo, Uruguay.
⁴ Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. vdsilva@ufba.br.
⁵ Laboratory of Neurochemistry and Cell Biology, Department of Biochemistry and Biophysics, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, 40110-100, Brazil. costasl@ufba.br.

^# Contributed equally.

PMID: 36800114
DOI: 10.1007/s12640-022-00632-1

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal illness characterized by progressive motor neuron degeneration. Conventional therapies for ALS are based on treatment of symptoms, and the disease remains incurable. Molecular mechanisms are unclear, but studies have been pointing to involvement of glia, neuroinflammation, oxidative stress, and glutamate excitotoxicity as a key factor. Nowadays, we have few treatments for this disease that only delays death, but also does not stop the neurodegenerative process. These treatments are based on glutamate blockage (riluzole), tyrosine kinase inhibition (masitinib), and antioxidant activity (edaravone). In the past few years, plant-derived compounds have been studied for neurodegenerative disorder therapies based on neuroprotection and glial cell response. In this review, we describe mechanisms of action of natural compounds associated with neuroprotective effects, and the possibilities for new therapeutic strategies in ALS.

Keywords: Amyotrophic lateral sclerosis; Glial cells; Motor neurons; Natural compounds; Neuroprotection.

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References

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[1] Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S (2019) Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: a review. Neuroscience 406:1–21. https://doi.org/10.1016/j.neuroscience.2019.02.020 - DOI - PubMed

[2] Abrahams S, Haylett WL, Johnson G, Carr JA, Bardien S (2019) Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: a review. Neuroscience 406:1–21. https://doi.org/10.1016/j.neuroscience.2019.02.020 - DOI - PubMed

[3] Al-Chalabi A, Hardiman O (2013) The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol 9(11):617–628. https://doi.org/10.1038/nrneurol.2013.203 - DOI - PubMed

[4] Al-Chalabi A, Hardiman O (2013) The epidemiology of ALS: a conspiracy of genes, environment and time. Nat Rev Neurol 9(11):617–628. https://doi.org/10.1038/nrneurol.2013.203 - DOI - PubMed

[5] Allaman I, Bélanger M, Magistretti PJ (2011) Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci 34(2):76–87. https://doi.org/10.1016/j.tins.2010.12.001 - DOI - PubMed

[6] Allaman I, Bélanger M, Magistretti PJ (2011) Astrocyte-neuron metabolic relationships: for better and for worse. Trends Neurosci 34(2):76–87. https://doi.org/10.1016/j.tins.2010.12.001 - DOI - PubMed

[7] Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML, Dickson DW (2007) TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer’s disease. Ann Neurol 61(5):435–445. https://doi.org/10.1002/ana.21154 - DOI - PubMed - PMC

[8] Amador-Ortiz C, Lin WL, Ahmed Z, Personett D, Davies P, Duara R, Graff-Radford NR, Hutton ML, Dickson DW (2007) TDP-43 immunoreactivity in hippocampal sclerosis and Alzheimer’s disease. Ann Neurol 61(5):435–445. https://doi.org/10.1002/ana.21154 - DOI - PubMed - PMC

[9] Anneser JM, Cookson MR, Ince PG, Shaw PJ, Borasio GD (2001) Glial cells of the spinal cord and subcortical white matter upregulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis. Exp Neurol 171(2):418–421. https://doi.org/10.1006/exnr.2001.7756 - DOI - PubMed

[10] Anneser JM, Cookson MR, Ince PG, Shaw PJ, Borasio GD (2001) Glial cells of the spinal cord and subcortical white matter upregulate neuronal nitric oxide synthase in sporadic amyotrophic lateral sclerosis. Exp Neurol 171(2):418–421. https://doi.org/10.1006/exnr.2001.7756 - DOI - PubMed

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Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis

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Impact of Plant-Derived Compounds on Amyotrophic Lateral Sclerosis

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