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Editorial
. 2023 Apr 1;324(4):H411-H413.
doi: 10.1152/ajpheart.00076.2023. Epub 2023 Feb 17.

The intersection between senescence-mediated vascular dysfunction and cognitive impairment in female mice

Anil Sakamuri  1 , Bernard Ojwang Ogola  1   2
Affiliations
Editorial

The intersection between senescence-mediated vascular dysfunction and cognitive impairment in female mice

Anil Sakamuri et al. Am J Physiol Heart Circ Physiol. .
No abstract available

Keywords: adrenergic receptors; aging; senescence; sex difference; vascular function.

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Conflict of interest statement

No conflicts of interest, financial or otherwise, are declared by the authors.

Figures

Figure 1.
Figure 1.
Factors impacting cognitive decline and vascular dysfunction. Early vascular aging, sex and gender, sex hormones, and sex chromosomes or their interaction can affect brain and vascular function. Image was created using a licensed version of BioRender.
See this image and copyright information in PMC

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References

    1. Ogola BO, Abshire CM, Visniauskas B, Kiley JX, Horton AC, Clark-Patterson GL, Kilanowski-Doroh I, Diaz Z, Bicego AN, McNally AB, Zimmerman MA, Groban L, Trask AJ, Miller KS, Lindsey SH. Sex differences in vascular aging and impact of GPER deletion. Am J Physiol Heart Circ Physiol 323: H336–H349, 2022. doi:10.1152/ajpheart.00238.2022. - DOI - PMC - PubMed
    1. Jiménez-Altayó F, Onetti Y, Heras M, Dantas AP, Vila E. Western-style diet modulates contractile responses to phenylephrine differently in mesenteric arteries from senescence-accelerated prone (SAMP8) and resistant (SAMR1) mice. Age (Dordr) 35: 1219–1234, 2013. doi:10.1007/s11357-012-9450-6. - DOI - PMC - PubMed
    1. Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ. Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function. Am J Physiol Heart Circ Physiol 313: H890–H895, 2017. doi:10.1152/ajpheart.00416.2017. - DOI - PMC - PubMed
    1. Johnson MD, Wray A. Alpha 1 adrenergic receptor function in senescent Fischer 344 rat aorta. Life Sci 46: 359–366, 1990. doi:10.1016/0024-3205(90)90015-j. - DOI - PubMed
    1. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. eNOS activity is reduced in senescent human endothelial cells: preservation by hTERT immortalization. Circ Res 89: 793–798, 2001. doi:10.1161/hh2101.098443. - DOI - PubMed

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