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. 2023 Aug 10;142(6):533-542.
doi: 10.1182/blood.2022017933.

Hematopoietic stem cell aging and leukemia transformation

Patricia A Colom Díaz  1 , Jayna J Mistry  1 , Jennifer J Trowbridge  1
Affiliations

Hematopoietic stem cell aging and leukemia transformation

Patricia A Colom Díaz et al. Blood. .

Erratum in

Abstract

With aging, hematopoietic stem cells (HSCs) have an impaired ability to regenerate, differentiate, and produce an entire repertoire of mature blood and immune cells. Owing to dysfunctional hematopoiesis, the incidence of hematologic malignancies increases among elderly individuals. Here, we provide an update on HSC-intrinsic and -extrinsic factors and processes that were recently discovered to contribute to the functional decline of HSCs during aging. In addition, we discuss the targets and timing of intervention approaches to maintain HSC function during aging and the extent to which these same targets may prevent or delay transformation to hematologic malignancies.

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Conflict of interest statement

Conflict-of-interest disclosure: J.J.T. receives royalties for patent licensing from Fate Therapeutics. The remaining authors declare no competing financial interests.

Figures

None
Graphical abstract
Figure 1.
Figure 1.
Phenotypic alterations in adult HSCs with increasing age in C57BL/6 mice and humans. ∗Supporting studies in mice and humans. #Supporting studies in mice. Illustration created using BioRender.com.
Figure 2.
Figure 2.
Potential targetable mechanisms to rejuvenate aged HSCs and prevent hematologic malignancy. Phenotypes and biological mechanisms implicated in HSC aging, hematologic malignancy, or both are shown on the left. As overlapping mechanisms represent the most compelling targets for intervention, the inset table outlines the potential targetable mechanisms discussed in detail in this review. Illustration created using BioRender.com.
See this image and copyright information in PMC

Comment in

References

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