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. 1987 Sep;20(3):399-404.
doi: 10.1093/jac/20.3.399.

Influence of various antibiotics on phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes

P Van der Auwera  1 , M Husson, J Frühling
Affiliations

Influence of various antibiotics on phagocytosis of Staphylococcus aureus by human polymorphonuclear leucocytes

P Van der Auwera et al. J Antimicrob Chemother. 1987 Sep.

Abstract

The influence of several new antibiotics on phagocytosis of two strains of Staphylococcus aureus by human polymorphonuclear leucocytes was studied with a radioisotopic method. The following antibiotics were tested in concentrations obtained in the serum after standard administration: gentamicin, netilmicin, amikacin, oxacillin, clindamycin, vancomycin, teicoplanin, rifampicin, ansamycin, coumermycin, enoxacin, ciprofloxacin, two new fluoro-quinolones CI 934 and RO 236240, and LY 146032 a new lipopeptidic antibiotic. Among them, only coumermycin significantly decreased phagocytosis, this was dependent on concentration, strain and source of the polymorphonuclear leucocytes.

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