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Observational Study
. 2023 Feb 17;21(1):15.
doi: 10.1186/s12955-023-02099-w.

Using the emotional functioning in clinical practice to detect psychological distress in patients with advanced thoracic and colorectal cancer

Adán Rodriguez-Gonzalez  1 , Raquel Hernández  2 , Patricia Cruz-Castellanos  3 , Ana Fernández-Montes  4 , Oscar Castillo-Trujillo  1 , María M Muñoz  5 , Juana M Cano-Cano  6 , María J Corral  7 , Emilio Esteban  1 , Paula Jiménez-Fonseca  1 , Caterina Calderon  8
Affiliations
Observational Study

Using the emotional functioning in clinical practice to detect psychological distress in patients with advanced thoracic and colorectal cancer

Adán Rodriguez-Gonzalez et al. Health Qual Life Outcomes. .

Abstract

Purpose: Patients with advanced cancer suffer significant decline of their psychological state. A rapid and reliable evaluation of this state is essential to detect and treat it and improve quality of life. The aim was to probe the usefulness of the emotional function (EF) subscale of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EF-EORTC-QLQ-C30) to assess psychological distress in cancer patients.

Methods: This is a multicenter, prospective, observational study involving 15 Spanish hospitals. Patients diagnosed with unresectable advanced thoracic or colorectal cancer were included. Participants completed the Brief Symptom Inventory 18 (BSI-18), the current the gold standard, and the EF-EORTC-QLQ-C30 to assess their psychological distress prior to initiating systemic antineoplastic treatment. Accuracy, sensitivity, positive predictive value (PPV), specificity, and negative predictive value (NPV) were calculated.

Results: The sample comprised 639 patients: 283 with advanced thoracic cancer and 356 with advanced colorectal cancer. According to the BSI scale, 74% and 66% displayed psychological distress with an EF-EORTC-QLQ-C30 accuracy of 79% and 76% in detecting psychological distress in individuals with advanced thoracic and colorectal cancer, respectively. Sensitivity was 79 and 75% and specificity was 79 and 77% with a PPV of 92 and 86% and a NPV of 56 and 61% (scale cut-off point, 75) for patients with advanced thoracic and colorectal cancer, respectively. The mean AUC for thoracic cancer was 0.84 and, for colorectal cancer, it was 0.85.

Conclusion: This study reveals that the EF-EORTC-QLQ-C30 subscale is a simple and effective tool for detecting psychological distress in people with advanced cancer.

Keywords: Advanced cancer; EORTC-QLQ-C30; Emotional function; Psychological distress; Sensitivity; Specificity.

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Conflict of interest statement

The authors declare that they have no competing interest.

Figures

Fig. 1
Fig. 1
Outcomes: true positive (TP), true negative (TN), false positive (FP), and false negative (FN) for unresectable advanced thoracic (TC) and colorectal cancer (CRC)
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References

    1. Seiler A, Jenewein J. Resilience in cancer patients. Front Psychiatry. 2019;10:208. doi: 10.3389/fpsyt.2019.00208. - DOI - PMC - PubMed
    1. Biller L, Schrag D. Diagnosis and treatment of metastatic colorectal cancer. JAMA. 2021;16:669. doi: 10.1001/jama.2021.0106. - DOI - PubMed
    1. Baidoun F, Elshiwy K, Elkeraire Y, et al. Colorectal cancer epidemiology: recent treds and impact on outcomes. Curr Drug Targets. 2021;22:998–1009. doi: 10.2174/18735592MTEx9NTk2y. - DOI - PubMed
    1. Mollica MA, Castro K, Smith AW, et al. Survivorship for individuals living with advanced and metastatic cancers: National Cancer Institute Meeting Report. JNCI J Natl Cancer Inst. 2022;114:489–495. doi: 10.1093/jnci/djab223. - DOI - PMC - PubMed
    1. Siegel RL, Miller KD, Fuch H, et al. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7–33. doi: 10.3322/caac.21590. - DOI - PubMed

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