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Editorial
. 2023 May;30(5):1165-1166.
doi: 10.1111/ene.15751. Epub 2023 Mar 3.

Long COVID: Does SARS-CoV-2 induce lingering brain lesions?

Jacques Hugon  1
Affiliations
Editorial

Long COVID: Does SARS-CoV-2 induce lingering brain lesions?

Jacques Hugon. Eur J Neurol. 2023 May.

Abstract

Hundreds of millions of COVID cases have been reported so far and long-term lingering clinical symptoms are frequent and are called long COVID. Neurological signs including cognitive complaints are often described in long Covid. In COVID patients, the Sars-Cov-2 virus can reach the brain and could be responsible for cerebral anomalies observed in long COVID. Long-term careful clinical follow-up of these patients is necessary to detect early signs of neurodegeneration.

Keywords: COVID-19; cognitive disorders; infections; mild cognitive impairment; neurological disorders.

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References

REFERENCES

    1. Functional Neurological Disorder in people with Long-Covid: A Systematic Review European Journal of Neurology. 2023;30(5):1505-1514. doi:10.1111/ene.14703
    1. Stein SR, Ramelli SC, Grazioli A, et al. SARS-CoV-2 infection and persistence in the human body and brain at autopsy. Nature. 2022;612:758-763. doi:10.1038/s41586-022-05542-y
    1. Mizrahi B, Sudry T, Flaks-Manov N, et al. Long covid outcomes at one year after mild SARS-CoV-2 infection: nationwide cohort study. BMJ. 2023;380:e072529. doi:10.1136/bmj-2022-072529
    1. Rothstein TL. Cortical Grey matter volume depletion links to neurological sequelae in post COVID-19 “long haulers”. BMC Neurol. 2023;23:22. doi:10.1186/s12883-023-03049-1
    1. Douaud G, Lee S, Alfaro-Almagro F, et al. SARS-CoV-2 is associated with changes in brain structure in UK biobank. Nature. 2022;604:697-707. doi:10.1038/s41586-022-04569-5

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