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Comment
. 2023 Feb 16;186(4):683-685.
doi: 10.1016/j.cell.2023.01.023.

Induced epigenetic changes memorized across generations in mice

Saifeng Cheng  1 , Yoav Mayshar  1 , Yonatan Stelzer  2
Affiliations
Comment

Induced epigenetic changes memorized across generations in mice

Saifeng Cheng et al. Cell. .

Abstract

Transgenerational epigenetic inheritance in mammals has long been debatable. In this issue of Cell, Takahashi et al. induce DNA methylation at promoter-associated CpG islands (CGIs) of two metabolism-related genes and show that the acquired epigenetic changes and associated metabolic phenotypes are stably propagated across several generations in transgenic mice.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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