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. 2023 Feb 21;23(1):45.
doi: 10.1186/s12902-023-01304-7.

Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

Zitu Barman  1 , Mahmudul Hasan  1 , Rakib Miah  1 , Ananya Dutta Mou  1 , Jaasia Momtahena Hafsa  1 , Aporajita Das Trisha  1 , Firoz Mahmud  1 , Nurshad Ali  2
Affiliations

Association between hyperuricemia and chronic kidney disease: a cross-sectional study in Bangladeshi adults

Zitu Barman et al. BMC Endocr Disord. .

Abstract

Background and aims: Chronic kidney disease (CKD) is a public health concern worldwide and has been recognized as a significant risk factor for cardiovascular disease. The elevated level of uric acid (hyperuricemia) has been suggested to be associated with obesity, hypertension, cardiovascular disease and diabetes. However, there is limited information on the relationship between hyperuricemia and CKD. Therefore, this study aimed to estimate the prevalence of CKD and assess its relationship with hyperuricemia in Bangladeshi adults.

Methods: In this study, blood samples were collected from 545 participants (398 males and 147 females) aged ≥ 18 years. Biochemical parameters such as serum uric acid (SUA), lipid profile markers, glucose, creatinine and urea were measured by colorimetric methods. The estimated glomerular filtration rate (eGFR) and CKD were determined based on serum creatinine levels with existed formula. Multivariate logistic regression analysis was performed to evaluate the association between SUA and CKD.

Results: The overall prevalence of CKD was 5.9% with 6.1% in males and 5.2% in females. Hyperuricemia was prevalent in 18.7% of participants with 23.2% in males and 14.6% in females. An increasing trend of CKD prevalence was observed with increasing age in the groups. The mean eGFR level was significantly lower in male (95.1 ± 31.8 ml/min/1.73m2) than in female (109.3 ± 77.4 ml/min/1.73m2) subjects (p < 0.01). The mean level of SUA was significantly higher (p < 0.01) in participants having CKD (7.1 ± 1.9 mg/dL) than in participants without CKD (5.7 ± 1.6 mg/dL). A decreasing trend for eGFR concentration and an increasing trend for CKD prevalence was observed across the SUA quartiles (p < 0.001). In regression analysis, a significant positive association was found between hyperuricemia and CKD.

Conclusion: This study showed an independent association between hyperuricemia and CKD in Bangladeshi adults. Further mechanistic studies are needed to explore the potential link between hyperuricemia and CKD.

Keywords: Bangladesh; Chronic kidney disease; Hyperuricemia; SUA; eGFR.

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Conflict of interest statement

The authors have no competing interests to declare.

Figures

Fig. 1
Fig. 1
Prevalence of CKD in healthy, diabetic and hypertensive individuals. P-value was obtained from one-way ANOVA.
Fig. 2
Fig. 2
Levels of eGFR in different age groups. P-value was obtained from one-way ANOVA.
Fig. 3
Fig. 3
Correlations of eGFR with SUA and BUN. P-values were obtained from Pearson’s correlation coefficient test
See this image and copyright information in PMC

References

    1. Levey AS, Coresh J, Bolton K, Culleton B, Harvey KS, Ikizler TA et al. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. WB Saunders Ltd; 2002;39:i-ii+.
    1. Nugent RA, Fathima SF, Feigl AB, Chyung D. The burden of chronic kidney disease on developing nations: a 21st century challenge in global health. Nephron Clin Pract Karger Publishers. 2011;118:c269–77. doi: 10.1159/000321382. - DOI - PubMed
    1. Zhang L, Wang F, Wang L, Wang W, Liu B, Liu J, et al. Prevalence of chronic kidney disease in China: a cross-sectional survey. The lancet Elsevier. 2012;379:815–22. doi: 10.1016/S0140-6736(12)60033-6. - DOI - PubMed
    1. Glantzounis GK, Tsimoyiannis EC, Kappas AM, Galaris DA. Uric acid and oxidative stress. Curr Pharm Des Bentham Science Publishers. 2005;11:4145–51. - PubMed
    1. Remedios C, Shah M, Bhasker AG, Lakdawala M. Hyperuricemia: a reality in the indian obese. Obes Surg Springer. 2012;22:945–8. doi: 10.1007/s11695-012-0655-7. - DOI - PubMed