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Review
. 2023 Feb 20;23(1):29.
doi: 10.1186/s12935-023-02868-z.

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

Mahboobeh Faramin Lashkarian #  1 , Nasrin Hashemipour #  2 , Negin Niaraki  3 , Shahrad Soghala  4 , Ali Moradi  5 , Sareh Sarhangi  6 , Mahsa Hatami  7 , Fatemehsadat Aghaei-Zarch  8 , Mina Khosravifar  9 , Alireza Mohammadzadeh  10 , Sajad Najafi  11 , Jamal Majidpoor  12 , Poopak Farnia  13 , Seyed Mohsen Aghaei-Zarch  14
Affiliations
Review

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

Mahboobeh Faramin Lashkarian et al. Cancer Cell Int. .

Abstract

MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.

Keywords: Cancer; Pathogenesis; Prognosis; Therapy; miR-122.

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Conflict of interest statement

The authors declare that there is no competing interests.

Figures

Fig. 1
Fig. 1
Schematic representation of miR-122 biosynthesis and its role in cancer progression
Fig. 2
Fig. 2
miR-122 target different mRNA in different tissues
Fig. 3
Fig. 3
An overview of the regulatory role of miR-122 in cancer therapy resistance in different cancers. Recent studies have shown that miR-122 by targeting different proteins plays a major role in resistance to different cancer therapies
Fig. 4
Fig. 4
An overview of the regulatory role of miR-122 in cancer stem cells in different cancers. Recent studies demonstrated that miR-122 by targeting various proteins plays a crucial in the stemness of cancer stem cells
Fig. 5
Fig. 5
miR-122 replacement therapy via various tools to combat cancer
See this image and copyright information in PMC

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