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. 1979 Jan;137(1):694-6.
doi: 10.1128/jb.137.1.694-696.1979.

Accumulation of peptidyl tRNA is lethal to Escherichia coli

J R Menninger

Accumulation of peptidyl tRNA is lethal to Escherichia coli

J R Menninger. J Bacteriol. 1979 Jan.

Abstract

A mutant strain of Escherichia coli with temperature-sensitive peptidyl-tRNA hydrolase grows at 30 degrees C but, when shifted to 40 degrees C, dies at rates affected by physiological, pharmacological, and genetical perturbations. The rate of killing correlates with the relative accumulation of peptidyl-tRNA, suggesting that it is responsible for the death of the cells.

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References

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