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. 2023 Apr;164(5):752-765.
doi: 10.1053/j.gastro.2023.02.012. Epub 2023 Feb 18.

Pancreatic Cancer: Changing Epidemiology and New Approaches to Risk Assessment, Early Detection, and Prevention

Elena M Stoffel  1 , Randall E Brand  2 , Michael Goggins  3
Affiliations

Pancreatic Cancer: Changing Epidemiology and New Approaches to Risk Assessment, Early Detection, and Prevention

Elena M Stoffel et al. Gastroenterology. 2023 Apr.

Abstract

Pancreatic cancer usually results in poor survival with limited options for treatment, as most affected individuals present with advanced disease. Early detection of preinvasive pancreatic neoplasia and identifying molecular therapeutic targets provide opportunities for extending survival. Although screening for pancreatic cancer is currently not recommended for the general population, emerging evidence indicates that pancreatic surveillance can improve outcomes for individuals in certain high-risk groups. Changes in the epidemiology of pancreatic cancer, experience from pancreatic surveillance, and discovery of novel biomarkers provide a roadmap for new strategies for pancreatic cancer risk assessment, early detection, and prevention.

Keywords: Genetic Susceptibility; Pancreatic Cancer; Surveillance.

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Conflict of interest statement

Conflicts of interest The authors disclose no conflicts.

Figures

Figure 1.
Figure 1.
Clinical approach to early detection of pancreatic neoplasia. FDR, first-degree relative.
See this image and copyright information in PMC

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