Rewriting the message: Harnessing RNA pseudouridylation to tackle disease
- PMID: 36804913
- DOI: 10.1016/j.molcel.2023.02.001
Rewriting the message: Harnessing RNA pseudouridylation to tackle disease
Abstract
Adachi et al.1 and Song et al.2 demonstrate the feasibility of engineering pseudouridylation at specific sites and its utility to correct disease-causing premature termination codons (PTCs) in human cells.
Copyright © 2023. Published by Elsevier Inc.
Conflict of interest statement
Declaration of interests The authors declare no competing interests.
Comment on
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CRISPR-free, programmable RNA pseudouridylation to suppress premature termination codons.Mol Cell. 2023 Jan 5;83(1):139-155.e9. doi: 10.1016/j.molcel.2022.11.011. Epub 2022 Dec 14. Mol Cell. 2023. PMID: 36521489
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Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes.Mol Cell. 2023 Feb 16;83(4):637-651.e9. doi: 10.1016/j.molcel.2023.01.009. Epub 2023 Feb 9. Mol Cell. 2023. PMID: 36764303 Free PMC article.
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