Advances in antibody-based therapy in oncology

Sacha Zinn^{1

2}, Rodrigo Vazquez-Lombardi^{1

2

3}, Carsten Zimmermann^{4

5}, Puja Sapra⁶, Lutz Jermutus⁷, Daniel Christ^{8

9}

Affiliations

¹ Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
² Faculty of Medicine, The University of New South Wales, St Vincent's Clinical School, Darlinghurst, Sydney, New South Wales, Australia.
³ Engimmune Therapeutics, Allschwil, Switzerland.
⁴ University of San Diego, Knauss School of Business, San Diego, CA, USA.
⁵ University of California San Diego, La Jolla, CA, USA.
⁶ AstraZeneca, Oncology R&D, Biologics Engineering & Targeted Delivery, Gaithersburg, MD, USA.
⁷ AstraZeneca, BioPharmaceuticals R&D, Research & Early Development, Cambridge, UK.
⁸ Garvan Institute of Medical Research, Sydney, New South Wales, Australia. d.christ@garvan.org.au.
⁹ Faculty of Medicine, The University of New South Wales, St Vincent's Clinical School, Darlinghurst, Sydney, New South Wales, Australia. d.christ@garvan.org.au.

PMID: 36806801
DOI: 10.1038/s43018-023-00516-z

Review

Advances in antibody-based therapy in oncology

Sacha Zinn et al. Nat Cancer. 2023 Feb.

. 2023 Feb;4(2):165-180.

doi: 10.1038/s43018-023-00516-z. Epub 2023 Feb 20.

Authors

Sacha Zinn^{1

2}, Rodrigo Vazquez-Lombardi^{1

2

3}, Carsten Zimmermann^{4

5}, Puja Sapra⁶, Lutz Jermutus⁷, Daniel Christ^{8

9}

Affiliations

¹ Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
² Faculty of Medicine, The University of New South Wales, St Vincent's Clinical School, Darlinghurst, Sydney, New South Wales, Australia.
³ Engimmune Therapeutics, Allschwil, Switzerland.
⁴ University of San Diego, Knauss School of Business, San Diego, CA, USA.
⁵ University of California San Diego, La Jolla, CA, USA.
⁶ AstraZeneca, Oncology R&D, Biologics Engineering & Targeted Delivery, Gaithersburg, MD, USA.
⁷ AstraZeneca, BioPharmaceuticals R&D, Research & Early Development, Cambridge, UK.
⁸ Garvan Institute of Medical Research, Sydney, New South Wales, Australia. d.christ@garvan.org.au.
⁹ Faculty of Medicine, The University of New South Wales, St Vincent's Clinical School, Darlinghurst, Sydney, New South Wales, Australia. d.christ@garvan.org.au.

PMID: 36806801
DOI: 10.1038/s43018-023-00516-z

Abstract

Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by exquisite specificity, long serum half-life, high affinity and immune effector functions. In this review, we outline key advances in the field with a particular focus on recent and emerging classes of engineered antibody therapeutic candidates, discuss molecular structure and mechanisms of action and provide updates on clinical development and practice.

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References

1. Goulet, D. R. & Atkins, W. M. Considerations for the design of antibody-based therapeutics. J. Pharm. Sci. 109, 74–103 (2020). - PubMed - DOI
1. Sliwkowski, M. X. & Mellman, I. Antibody therapeutics in cancer. Science 341, 1192–1198 (2013). - PubMed - DOI
1. Pierpont, T. M., Limper, C. B. & Richards, K. L. Past, present, and future of rituximab—the world’s first oncology monoclonal antibody therapy. Front. Oncol. 8, 163 (2018). - PubMed - PMC - DOI
1. Forecast, M.D. Global Cancer Monoclonal Antibodies Market Size, Share, Trends, COVID-19 Impact & Growth Analysis Report – Segmented By Application, Type, Conjugate Cancer Therapies & Region – Industry Forecast (2021 to 2026), Vol. 2021 (Market Data Forecast, 2021).
1. Schroeder, H. W. Jr. & Cavacini, L. Structure and function of immunoglobulins. J. Allergy Clin. Immunol. 125, S41–S52 (2010). - PubMed - PMC - DOI

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Advances in antibody-based therapy in oncology

Affiliations

Advances in antibody-based therapy in oncology

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Medical