Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2023;27(2):96-102.
doi: 10.1007/s12603-023-1879-z.

Prevalence and Risk Factors of Frailty in Stroke Patients: A Meta-Analysis and Systematic Review

Y N Huang  1 , F H Yan, X Y Wang, X L Chen, H Y Chong, W L Su, Y R Chen, L Han, Y X Ma
Affiliations
Meta-Analysis

Prevalence and Risk Factors of Frailty in Stroke Patients: A Meta-Analysis and Systematic Review

Y N Huang et al. J Nutr Health Aging. 2023.

Abstract

Objectives: Summarize the existing evidence regarding the prevalence and risk factors of frailty in stroke patients.

Design: A meta-analysis and systematic review.

Participants: Stroke patients in hospitals or communities.

Methods: We undertook a systematic review and meta-analysis using articles available in 8 databases, including PubMed, The Cochrane Library, Web of Science, Embase, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure Database (CNKI), Wanfang Database, and Weipu Database (VIP) from January 1990 to April 2022. Studies were quality rated using the Newcastle-Ottawa Scale and Agency for Healthcare Research and Quality tool.

Results: A total of 24 studies involving 30,423 participants were identified. The prevalence of frailty and pre-frailty in stroke patients was 27% (95%CI: 0.23-0.31) and 47.9% (95%CI: 0.43-0.53). Female gender (OR = 1.76, 95%CI: 1.63-1.91), advanced age (MD = 6.73, 95%CI: 3.55-9.91), diabetes (OR = 1.34, 95%CI: 1.06-1.69), hyperlipidemia (OR = 1.46, 95%CI: 1.04-2.04), atrial fibrillation (OR = 1.36, 95%CI: 1.01-1.82), National Institutes of Stroke Scale (NIHSS) admission scores (MD = 2.27, 95%CI: 1.72-2.81) were risk factors of frailty in stroke patients.

Conclusions: Frailty was more prevalent in stroke patients. Female gender, advanced age, diabetes, hyperlipidemia, atrial fibrillation, and National Institutes of Stroke Scale (NIHSS) admission scores were identified as risk factors for frailty in stroke patients. In the future, medical staff should pay attention to the early screening of frailty in high-risk groups and provide information on its prevention.

Keywords: Stroke; frailty; meta-analysis; prevalence; risk factor.

PubMed Disclaimer

Conflict of interest statement

None authors have financial disclosures or conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of the searching and screening Note. Taylor-Rowan 2019 (1): Pre-stroke frailty is independently associated with post-stroke cognition: a cross-sectional study; Taylor-Rowan 2019 (2): The prevalence of frailty among acute stroke patients, and evaluation of method of assessment.
Figure 2
Figure 2
Forest plot from the meta-analysis of frailty prevalence data
Figure 3
Figure 3
Forest plot from the meta-analysis of pre-frailty prevalence data
See this image and copyright information in PMC

References

    1. Johnson CO, Nguyen M, Roth GA. Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(5):439–458. 10.1016/S1474-4422(19)30034-1 - DOI - PMC - PubMed
    1. Wang LD, Liu JM, Yang G, et al. Brief report on stroke prevention and treatment in China, 2020. Chinese Circulation Journal. 2019;34(2):105–119. [in Chinese]
    1. Feigin VL, Stark BA, Johnson CO, et al. Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol. 2021;20(10):795–820. 10.1016/S1474-4422(21)00252-0 - DOI - PMC - PubMed
    1. Tu WJ, Hua Y, Yan F, et al. Prevalence of stroke in China, 2013–2019: A population-based study. The Lancet Regional Health — Western Pacific. 2022; 10050. 10.1016/j.lanwpc.2022.100550. - DOI
    1. Smithard DG. Stroke in frail older people. Geriatrics. 2017;2(3):24. 10.3390/geriatrics2030024 PubMed PMID: 31011034; PMCID 6371123. - DOI - PMC - PubMed

Publication types