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Review
. 2023 Apr;21(2):228-240.
doi: 10.1007/s11914-023-00775-w. Epub 2023 Feb 21.

Wnt/β-Catenin Signaling in Craniomaxillofacial Osteocytes

Pedro L Cuevas  1 , Fabiana Aellos  1 , Isaiah M Dawid  1 , Jill A Helms  2
Affiliations
Review

Wnt/β-Catenin Signaling in Craniomaxillofacial Osteocytes

Pedro L Cuevas et al. Curr Osteoporos Rep. 2023 Apr.

Abstract

Purpose of review: There is a growing appreciation within the scientific community that cells exhibit regional variation. Whether the variation is attributable to differences in embryonic origin or anatomical location and mechanical loading has not been elucidated; what is clear, however, is that adult cells carry positional information that ultimately affects their functions. The purpose of this review is to highlight the functions of osteocytes in the craniomaxillofacial (CMF) skeleton as opposed to elsewhere in the body, and in doing so gain mechanistic insights into genetic conditions and chemically-induced diseases that particularly affect this region of our anatomy.

Recent findings: In the CMF skeleton, elevated Wnt/β-catenin signaling affects not only bone mass and volume, but also mineralization of the canalicular network and osteocyte lacunae. Aberrant elevation in the Wnt/β-catenin pathway can also produce micropetrosis and osteonecrosis of CMF bone, presumably due to a disruption in the signaling network that connects osteocytes to one another, and to osteoblasts on the bone surface.

Keywords: Canalicular network; Craniofacial; Mandible; Maxilla; Micropetrosis; Mineralization; Osteonecrosis.

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References

    1. Goldring, S. R. The osteocyte: key player in regulating bone turnover. RMD Open 2015; 1: e000049 2015. https://doi.org/10.1136/rmdopen-2015-000049 .
    1. Heino TJ, Kurata K, Higaki H, Vaananen HK. Evidence for the role of osteocytes in the initiation of targeted remodeling. Technol Health Care. 2009;17:49–56. https://doi.org/10.3233/THC-2009-0534 . - DOI - PubMed
    1. Kelder C, Kleverlaan C J, Gilijamse M, Bakker A D & de Vries T J Cells derived from human long bone appear more differentiated and more actively stimulate osteoclastogenesis compared to alveolar bone-derived cells. Int J Mol Sci 2020;21. https://doi.org/10.3390/ijms21145072.
    1. Wan Q, et al. Osteoblasts of calvaria induce higher numbers of osteoclasts than osteoblasts from long bone. Bone. 2016;86:10–21. https://doi.org/10.1016/j.bone.2016.02.010 . - DOI - PubMed
    1. Cane V, et al. Size and density of osteocyte lacunae in different regions of long bones. Calcif Tissue Int. 1982;34:558–63. https://doi.org/10.1007/BF02411304 . - DOI - PubMed

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