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. 2023 May-Jun;61(3):301-303.
doi: 10.1111/gwat.13303. Epub 2023 Feb 25.

EPA's Unprecedented Interim Drinking Water Health Advisories for PFOA and PFOS

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EPA's Unprecedented Interim Drinking Water Health Advisories for PFOA and PFOS

Joseph A Cotruvo et al. Ground Water. 2023 May-Jun.

Abstract

Per- and polyfluoroalkyl substances (PFAS) are persistent and widely distributed in the environment from commercial products and waste process residues, including in surface waters usually at low parts per trillion (ppt) levels. Groundwaters near contaminated locations can have higher parts per trillion or parts per billion (ppb) concentrations. Interim EPA Drinking Water Health Advisories (HAs) for perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) that were originally 70 ppt were recently reduced to 0.004 and 0.020 ppt, respectively. Final HAs for perfluorobutane sulfonic acid and its potassium salt (PFBS) and hexafluoropropylene oxide (HFPO) dimer acid and its ammonium salt ("GenX chemicals") were established at 2000 and 10 ppt, respectively. The minimum reporting levels (MRLs) for PFOA and PFOS are currently 4 ppt. The scientific basis for these very low and unmeasurable HA values for PFOA and PFOS is debatable and up to about five orders of magnitude below many other worldwide national recommendations (e.g., Australia, UK, Canada), which are in the range of 100 ppt and above.

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References

    1. Antoniou, E., T. Colnut, M. Zeegers, and W. Dekant. 2022. Immunomodulation and exposure to per- and polyfluoroalkyl substances: An overview of the current evidence from animal and human studies. Archives of Toxicology 96, no. 8: 2261-2285 https://pubmed.ncbi.nlm.nih.gov/35695909/
    1. Agency for Toxic Substances and Disease Registry (ATSDR). 2022. Per- and polyfluoroalkyl substances (PFAS) and your health. PFAS in the population. https://www.atsdr.cdc.gov/pfas/health-effects/us-population.html
    1. Budtz-Jorgensen, E., and P. Grandjean. 2018. Application of benchmark analysis for mixed contaminant exposures: Mutual adjustment for perfluoroalkylate substances associated with immunotoxicity. PLoS One 13, no. 10: e0205388 https://pubmed.ncbi.nlm.nih.gov/30339706/
    1. Centers for Disease Control and Prevention (CDC). Atlanta, GA. 2021a. Diphtheria. Pink Book, 14th ed. https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/dip.pdf
    1. Centers for Disease Control and Prevention (CDC), Atlanta, GA. 2021b. Tetanus. Pink Book, 14th ed. https://www.cdc.gov/vaccines/pubs/pinkbook/tetanus.html

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