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Review
. 2023 Mar;118(2):107-113.
doi: 10.1007/s00063-023-00993-1. Epub 2023 Feb 17.

[Bacterial gut microbiota-key player in sepsis]

[Article in German]
Matthias Lindner  1 , David I Radke  2 , Gunnar Elke  2
Affiliations
Review

[Bacterial gut microbiota-key player in sepsis]

[Article in German]
Matthias Lindner et al. Med Klin Intensivmed Notfmed. 2023 Mar.

Abstract
in English, German

The gut microbiota is comprised of over 1200 different bacteria and forms a symbiotic community with the human organism, the holobiont. It plays an important role in the maintenance of homeostasis, e.g., of the immune system and essential metabolic processes. Disturbances in the balance of this reciprocal relationship are called dysbiosis and, in the field of sepsis, are associated with incidence of disease, extent of the systemic inflammatory response, severity of organ dysfunction, and mortality. In addition to providing guiding principles in the fascinating relationship between "human and microbe," this article summarizes recent findings regarding the role of the bacterial gut microbiota in sepsis, which is one a very relevant in intensive care medicine.

Das bakterielle intestinale Mikrobiom ist aus über 1200 verschiedenen Spezies zusammengesetzt und bildet mit dem menschlichen Organismus eine symbiotische Lebensgemeinschaft, den „Holobionten“. Es spielt in der Aufrechterhaltung der Homöostase z. B. des Immunsystems und essenzieller metabolischer Prozesse eine wichtige Rolle. Störungen des Gleichgewichts dieser wechselseitigen Beziehung werden Dysbiose genannt und sind im Bereich der Sepsis mit Erkrankungshäufigkeit, Ausmaß der Ausprägung der systemischen Inflammationsreaktion, Schweregrad der Organdysfunktionen und Mortalität assoziiert. Neben den orientierenden Grundlagen in der faszinierenden Beziehung zwischen „Mensch und Mikrobe“ werden in diesem Artikel aktuelle Forschungsergebnisse im Hinblick auf die Rolle des intestinalen bakteriellen Mikrobioms in einem der wichtigsten intensivmedizinischen Krankheitsbilder zusammengefasst.

Keywords: Dysbiosis; Fecal microbiota transplantation; High-throughput nucleotide sequencing; Inflammation; Pathologic processes.

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References

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