Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Mar;49(3):273-290.
doi: 10.1007/s00134-023-06980-6. Epub 2023 Feb 17.

How to manage coagulopathies in critically ill patients

Julie Helms  1   2 , Toshiaki Iba  3 , Jean Marie Connors  4 , Satoshi Gando  5   6 , Marcel Levi  7   8 , Ferhat Meziani  9   10 , Jerrold H Levy  11
Affiliations
Review

How to manage coagulopathies in critically ill patients

Julie Helms et al. Intensive Care Med. 2023 Mar.

Abstract

Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical phenotype, the current review differentiates between hemorrhagic coagulopathies, characterized by a hypocoagulable and hyperfibrinolysis state, and thrombotic coagulopathies with a systemic prothrombotic and antifibrinolytic phenotype. We discuss the differences in pathogenesis and treatment of the common coagulopathies.

Keywords: Coagulopathy; Critical care; Disseminated intravascular coagulation; Hematological disease; Sepsis; Trauma.

PubMed Disclaimer

References

    1. Hjorleifsson E, Sigurdsson MI, Gudmundsdottir BR, Sigurdsson GH, Onundarson PT (2015) Prediction of survival in patients suspected of disseminated intravascular coagulation. Acta Anaesthesiol Scand 59:870–880. https://doi.org/10.1111/aas.12537 - DOI - PubMed
    1. Kleinveld DJB, Hamada SR, Sandroni C (2022) Trauma-induced coagulopathy. Intensive Care Med. https://doi.org/10.1007/s00134-022-06834-7 - DOI - PubMed
    1. Callcut RA, Kornblith LZ, Conroy AS, Robles AJ, Meizoso JP, Namias N, Meyer DE, Haymaker A, Truitt MS, Agrawal V, Haan JM, Lightwine KL, Porter JM, San Roman JL, Biffl WL, Hayashi MS, Sise MJ, Badiee J, Recinos G, Inaba K, Schroeppel TJ, Callaghan E, Dunn JA, Godin S, McIntyre RC Jr, Peltz ED, O’Neill PJ, Diven CF, Scifres AM, Switzer EE, West MA, Storrs S, Cullinane DC, Cordova JF, Moore EE, Moore HB, Privette AR, Eriksson EA, Cohen MJ, Western Trauma Association Multicenter Study G (2019) The why and how our trauma patients die: a prospective Multicenter Western Trauma Association study. J Trauma Acute Care Surg 86:864–870. https://doi.org/10.1097/TA.0000000000002205 - DOI - PMC - PubMed
    1. McLintock C (2020) Prevention and treatment of postpartum hemorrhage: focus on hematological aspects of management. Hematol Am Soc Hematol Educ Progr 2020:542–546. https://doi.org/10.1182/hematology.2020000139 - DOI
    1. Raza I, Davenport R, Rourke C, Platton S, Manson J, Spoors C, Khan S, De’Ath HD, Allard S, Hart DP, Pasi KJ, Hunt BJ, Stanworth S, MacCallum PK, Brohi K (2013) The incidence and magnitude of fibrinolytic activation in trauma patients. J Thromb Haemost 11:307–314. https://doi.org/10.1111/jth.12078 - DOI - PubMed

MeSH terms

LinkOut - more resources