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Review
. 2023 Feb 9;8(1):72.
doi: 10.3390/biomimetics8010072.

Drug-Eluting Stents: Technical and Clinical Progress

Maciej Koźlik  1 , Jan Harpula  1 , Piotr J Chuchra  2 , Magdalena Nowak  2 , Wojciech Wojakowski  1 , Paweł Gąsior  1
Affiliations
Review

Drug-Eluting Stents: Technical and Clinical Progress

Maciej Koźlik et al. Biomimetics (Basel). .

Abstract

Drug-eluting stents (DES) demonstrated superior efficacy when compared to bare metal stents and plain-old balloon angioplasty and are nowadays used in almost all percutaneous revascularization procedures. The design of the stent platforms is constantly improving to maximize its efficacy and safety. Constant development of DES includes adoption of new materials used for scaffold production, new design types, improved overexpansion abilities, new polymers coating and, finally, improved antiproliferative agents. Especially nowadays, with the immense number of available DES platforms, it is crucial to understand how different aspects of stents impact the effect of their implantation, as subtle differences between various stent platforms could impact the most important issue-clinical outcomes. This review discusses the current status of coronary stents and the impact of stent material, strut design and coating techniques on cardiovascular outcomes.

Keywords: coating technique; drug; drug-eluting stents; overexpansion; polymer; scaffold.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Estimated visualization of mechanical properties of the commonly used alloys.
Figure 2
Figure 2
Stent cells geometry.
Figure 3
Figure 3
Overexpansion capabilities.
Figure 4
Figure 4
Polymer distribution: conformal vs. abluminal.
See this image and copyright information in PMC

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