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. 2023 Apr;45(4):e2200229.
doi: 10.1002/bies.202200229. Epub 2023 Feb 22.

ORChestra coordinates the replication and repair music

Dazhen Liu  1 , Jay Sonalkar  1 , Supriya G Prasanth  1   2
Affiliations

ORChestra coordinates the replication and repair music

Dazhen Liu et al. Bioessays. 2023 Apr.

Abstract

Error-free genome duplication and accurate cell division are critical for cell survival. In all three domains of life, bacteria, archaea, and eukaryotes, initiator proteins bind replication origins in an ATP-dependent manner, play critical roles in replisome assembly, and coordinate cell-cycle regulation. We discuss how the eukaryotic initiator, Origin recognition complex (ORC), coordinates different events during the cell cycle. We propose that ORC is the maestro driving the orchestra to coordinately perform the musical pieces of replication, chromatin organization, and repair.

Keywords: DNA repair; DNA replication; ORC; cell cycle; chromatin; pre-replication complex.

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Figures

Figure 1:
Figure 1:
Schematic representation of the role of pre RC proteins in DNA replication initiation and DNA damage response and repair. BioRender was utilized to design the schematic.
See this image and copyright information in PMC

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