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Review
. 2023 Apr;27(2):91-104.
doi: 10.1111/hdi.13071. Epub 2023 Feb 22.

Chronic kidney disease-associated pruritus in patients undergoing hemodialysis: Xerosis and topical therapy

Arum Krismi  1   2 , Retno Danarti  3 , Ida I Dewa Putu Pramantara Setiabudi  4 , Yohanes W Wirohadidjojo  3
Affiliations
Review

Chronic kidney disease-associated pruritus in patients undergoing hemodialysis: Xerosis and topical therapy

Arum Krismi et al. Hemodial Int. 2023 Apr.

Abstract

Chronic kidney disease-associated pruritus (CKD-aP) is a common and distressing symptom for patients with CKD and a difficult challenge for nephrologists and dermatologists. Recent results showed the multifactorial nature of the pathophysiology, and therapeutic trials were only successful in certain subsets of patients. The clinical manifestations are varied, with xerosis being the most common dermatological manifestation and correlated with the intensity of CKD-aP. A better understanding of the pathophysiology of xerosis in CKD-aP and appropriate topical treatment could correct xerosis to reduce the intensity of CKD-aP and improve the patient's quality of life.

Keywords: chronic kidney disease; moisturizers; pruritus; topical treatment; xerosis.

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References

REFERENCES

    1. Germain MJ. Uremic pruritus: an itch with ominous consequences. Am J Nephrol. 2017;46(6):448-9.
    1. Weisshaar E, Ofenloch RF. One step closer to alleviating uraemic pruritus. Nat Rev Nephrol. 2020;16(4):189-90.
    1. KDIGO. KDIGO 2012 clinical practice guideline for the evaluation and management of chronic kidney disease: referral to specialists and models of care. Kidney Int Suppl. 2013;3:112-9.
    1. Weiss M, Mettang T, Tschulena U, Passlick-Deetjen J, Weisshaar E. Prevalence of chronic itch and associated factors in haemodialysis patients: a representative cross-sectional study. Acta Derm Venereol. 2015;95(7):816-21.
    1. Solak B, Acikgoz SB, Sipahi S, Erdem T. Epidemiology and determinants of pruritus in pre-dialysis chronic kidney disease patients. Int Urol Nephrol. 2016;48(4):585-91.

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