Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Apr;31(2):755-772.
doi: 10.1007/s10787-023-01157-5. Epub 2023 Feb 22.

The wound healing effect of botanicals and pure natural substances used in in vivo models

S A El-Sherbeni  1 , W A Negm  2
Affiliations
Review

The wound healing effect of botanicals and pure natural substances used in in vivo models

S A El-Sherbeni et al. Inflammopharmacology. 2023 Apr.

Abstract

Repairing the wound is a multistep process that includes the spatial and temporal synchronization of a different range of cell types to increase the speed of wound contraction, the proliferation of epithelial cells, and collagen formation. The need for proper management of acute wounds to be cured and not turned into chronic wounds is a significant clinical challenge. The traditional practice of medicinal plants in many regions of the world has been used in wound healing since ancient times. Recent scientific research introduced evidence of the efficacy of medicinal plants, their phyto-components, and the mechanisms underlying their wound-repairing activity. This review aims to briefly highlight the wound-curing effect of different plant extracts and purely natural substances in excision, incision, and burn experimental animal models with or without infection of mice, rats (diabetic and nondiabetic), and rabbits in the last 5 years. The in vivo studies represented reliable evidence of how powerful natural products are in healing wounds properly. They have good scavenging activity against Reactive oxygen species (ROS) and anti-inflammatory and antimicrobial effects that help in the process of wound healing. It is evident that incorporating bioactive natural products into wound dressings of bio- or synthetic polymers in nanofiber, hydrogel, film, scaffold, and sponge forms showed promising results in different phases of the wound-curing process of haemostasis, inflammation, growth, re-epithelialization, and remodelling.

Keywords: Animal models; Burns; Inflammation; Natural products; Wound dressings; Wound healing.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Different phases of skin wound healing
Fig. 2
Fig. 2
Structures of natural pure substances were investigated using wound healing in vivo models (animal models)
See this image and copyright information in PMC

References

    1. Aburjai T, Al-Janabi R, Al-Mamoori F, Azzam H. In vivo wound healing and antimicrobial activity of Alkanna strigose. Wound Med. 2019;25(1):100152. doi: 10.1016/j.wndm.2019.100152. - DOI
    1. Aderibigbe BA, Buyana B. Alginate in wound dressings. Pharmaceutics. 2018;10(2):42. doi: 10.3390/pharmaceutics10020042. - DOI - PMC - PubMed
    1. Ahmed OM, Mohamed T, Moustafa H, Hamdy H, Ahmed RR, Aboud E. Quercetin and low level laser therapy promote wound healing process in diabetic rats via structural reorganization and modulatory effects on inflammation and oxidative stress. Biomed Pharmacother. 2018;101:58–73. doi: 10.1016/j.biopha.2018.02.040. - DOI - PubMed
    1. Ajmal G, Bonde GV, Mittal P, Khan G, Pandey VK, Bakade BV, Mishra B. Biomimetic PCL-gelatin based nanofibers loaded with ciprofloxacin hydrochloride and quercetin: a potential anti-bacterial and antioxidant dressing material for accelerated healing of a full thickness wound. Int J Pharm. 2019;567:118480. doi: 10.1016/j.ijpharm.2019.118480. - DOI - PubMed
    1. Ajmal G, Bonde GV, Thokala S, Mittal P, Khan G, Singh J, Pandey VK, Mishra B. Ciprofloxacin HCl and quercetin functionalized electrospun nanofiber membrane: fabrication and its evaluation in full thickness wound healing. Artif Cells Nanomed Biotechnol. 2019;47(1):228–240. doi: 10.1080/21691401.2018.1548475. - DOI - PubMed

LinkOut - more resources