Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Implications for Clinical Trials
- PMID: 36812142
- PMCID: PMC10441563
- DOI: 10.1093/ecco-jcc/jjad029
Artificial Intelligence in Inflammatory Bowel Disease Endoscopy: Implications for Clinical Trials
Abstract
Artificial intelligence shows promise for clinical research in inflammatory bowel disease endoscopy. Accurate assessment of endoscopic activity is important in clinical practice and inflammatory bowel disease clinical trials. Emerging artificial intelligence technologies can increase efficiency and accuracy of assessing the baseline endoscopic appearance in patients with inflammatory bowel disease and the impact that therapeutic interventions may have on mucosal healing in both of these contexts. In this review, state-of-the-art endoscopic assessment of mucosal disease activity in inflammatory bowel disease clinical trials is described, covering the potential for artificial intelligence to transform the current paradigm, its limitations, and suggested next steps. Site-based artificial intelligence quality evaluation and inclusion of patients in clinical trials without the need for a central reader is proposed; for following patient progress, a second reading using AI alongside a central reader with expedited reading is proposed. Artificial intelligence will support precision endoscopy in inflammatory bowel disease and is on the threshold of advancing inflammatory bowel disease clinical trial recruitment.
Keywords: Endoscopy; imaging.
© The Author(s) 2023. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation.
Conflict of interest statement
HAA and JBC are employees of Bristol Myers Squibb. JEE reports personal fees from Boston Scientific, Falk, Lumendi, Paion, and Satisfai Health, outside the submitted work; in addition, JEE has a patent Methods and framework for assessing image quality issued, and a patent Quantification of Barrett’s oesophagus issued. RP reports personal fees from Abbott, AbbVie, Alimentiv [formerly Robarts], Amgen, Arena Pharmaceuticals, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Celltrion, Cosmos Pharmaceuticals, Eisai, Elan, Lilly, Ferring, Fresenius Kabi, Galapagos, Genentech, Gilead Sciences, GlaxoSmithKline, HC3 Communications, Janssen, Meducom, Merck, Mylan, Oppilan, Organon, Pandion Pharma, Pfizer, Progenity, Protagonist Therapeutics, Receptos, Roche, Sandoz, Satisfai Health, Schering-Plough, Shire, Sublimity Therapeutics, Takeda, Theravance Biopharma, Trellus Health, and UCB. ST has served as a paid consultant to AbbVie, Allergan, Amgen, Asahi, Bioclinica, Biogen, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, ChemoCentryx, Cosmo, Enterome, Equillium, Ferring, GSK, Genentech, Genzyme, Giuliani SpA, Immunocore, Immunometabolism, Janssen, Lilly, MSD, Merck, Mestag, Neovacs, Novo Nordisk, NPS Pharmaceuticals, Pfizer, Proximagen, Receptos, Roche, Satisfai Health, Sensyne Health, Shire, Sigmoid Pharma, Sorriso, Takeda, Topivert, UCB, VHsquared, Vifor, and Zeria; he has received grants and/or has grants pending from AbbVie, ECCO, Helmsley Trust, IOIBD, Janssen, Lilly, Norman Collisson Foundation, Pfizer, UCB, UKIERI, and Vifor; he has received honoraria from AbbVie, Amgen, Biogen, Ferring, Lilly, Pfizer, and Takeda; and he has had travel/accommodation expenses covered or reimbursed by AbbVie, Amgen, Biogen, Ferring, Lilly, Johnson & Johnson, Pfizer, and Takeda. KU was an employee of Bristol Myers Squibb at the time of manuscript initiation; he reports personal fees from Arena, Bristol Myers Squibb, Crinetics Pharmaceuticals, Insmed, and Locust Walk Capital. MFB is CEO and Founder of Satisfai Health.
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