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. 2023 Mar 1;22(1):31-39.
doi: 10.1097/HPC.0000000000000311. Epub 2023 Jan 11.

Erythrocyte Indices in Patients With Takotsubo Syndrome

Annabella Braschi  1 , Arian Frasheri  2 , Renzo M Lombardo  2 , Maurizio G Abrignani  3 , Rosalia Lo Presti  1 , Daniele Vinci  2 , Marcello Traina  1
Affiliations

Erythrocyte Indices in Patients With Takotsubo Syndrome

Annabella Braschi et al. Crit Pathw Cardiol. .

Abstract

Background: Although the prognosis of patients with Takotsubo syndrome (TTS) is relatively favorable, serious complications may occur. This study aimed to investigate the relationship between blood parameters and the occurrence of in-hospital complications.

Methods: Clinical charts of 51 patients with TTS were retrospectively evaluated, and data regarding blood parameters assessed during the first 24 hours of hospitalization were studied.

Results: Levels of hemoglobin less than 13 g/dL in men and 12 g/dL in women (P < 0.01), levels of mean corpuscular hemoglobin concentration (MCHC) less than 33 g/dL (P = 0.01), and levels of red blood cell distribution width-coefficient of variation higher than 14.5% (P = 0.01) were significantly associated to the occurrence of major adverse cardiovascular events (MACE). Markers, such as, platelets to lymphocytes ratio, lymphocytes to monocytes ratio, neutrophils to lymphocytes ratio, and white blood cell count to mean platelet volume, were unable to differentiate patients with and without complications (P > 0.05). MCHC and estimated glomerular filtration rate were independent predictors of MACE.

Conclusions: Blood parameters may have a role in the stratification risk of patients with TTS. Patients showing low levels of MCHC and decreased estimated glomerular filtration rate were more likely to have in-hospital MACE. This should encourage physicians to closely monitor blood parameters in patients with TTS.

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References

    1. Prasad A, Lerman A, Rihal CS. Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction. Am Heart J. 2008;155:408–417.
    1. Guerra F, Giannini I, Capucci A. The ECG in the differential diagnosis between takotsubo cardiomyopathy and acute coronary syndrome. Expert Rev Cardiovasc Ther. 2017;15:137–144.
    1. Parodi G, Citro R, Bellandi B, et al.; Tako-tsubo Italian Network (TIN). Tako-tsubo Italian Network (TIN). Revised clinical diagnostic criteria for Tako-tsubo syndrome: the Tako-tsubo Italian Network proposal. Int J Cardiol. 2014;172:282–283.
    1. Singh K, Carson K, Shah R, et al. Meta-analysis of clinical correlates of acute mortality in takotsubo cardiomyopathy. Am J Cardiol. 2014;113:1420–1428.
    1. Redfors B, Vedad R, Angerås O, et al. Mortality in takotsubo syndrome is similar to mortality in myocardial infarction-A report from the SWEDEHEART registry. Int J Cardiol. 2015;185:282–289.

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