Moving toward precision medicine with lung cancer organoids
- PMID: 36812886
- PMCID: PMC9975324
- DOI: 10.1016/j.xcrm.2023.100952
Moving toward precision medicine with lung cancer organoids
Abstract
In this issue of Cell Reports Medicine, Wang et al.1 generated 160 human lung cancer organoids, primarily from malignant effusions, and tested their responses to clinically used drugs to determine whether the ex vivo organoid responses predicted patient responses.
Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests J.K. is a member of a scientific advisory board for Sanofi and consults for Pulmatrix, Inc. J.D.M. receives royalties from the NCI and UT Southwestern Medical Center for distribution of human tumor cell lines.
Comment on
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Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study.Cell Rep Med. 2023 Feb 21;4(2):100911. doi: 10.1016/j.xcrm.2022.100911. Epub 2023 Jan 18. Cell Rep Med. 2023. PMID: 36657446 Free PMC article.
References
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- Ma H.-C., Zhu Y.-J., Zhou R., Yu Y.-Y., Xiao Z.-Z., Zhang H.-B. Lung cancer organoids, a promising model still with long way to go. Crit. Rev. Oncol. Hematol. 2022;171 - PubMed
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- Shi R., Radulovich N., Ng C., Liu N., Notsuda H., Cabanero M., Martins-Filho S.N., Raghavan V., Li Q., Mer A.S., et al. Organoid cultures as preclinical models of non-small cell lung cancer. Clin. Cancer Res. 2020;26:1162–1174. - PubMed
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