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Comment
. 2023 Feb 21;4(2):100952.
doi: 10.1016/j.xcrm.2023.100952.

Moving toward precision medicine with lung cancer organoids

Affiliations
Comment

Moving toward precision medicine with lung cancer organoids

James Kim et al. Cell Rep Med. .

Abstract

In this issue of Cell Reports Medicine, Wang et al.1 generated 160 human lung cancer organoids, primarily from malignant effusions, and tested their responses to clinically used drugs to determine whether the ex vivo organoid responses predicted patient responses.

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Conflict of interest statement

Declaration of interests J.K. is a member of a scientific advisory board for Sanofi and consults for Pulmatrix, Inc. J.D.M. receives royalties from the NCI and UT Southwestern Medical Center for distribution of human tumor cell lines.

Comment on

References

    1. Wang H.-M., Zhang C.-Y., Peng K.-C., Chen Z.-X., Su J.-W., Li Y.-F., Li W.-F., Gao Q.-Y., Zhang S.-L., Chen Y.-Q., et al. Using patient-derived organoids to predict locally advanced or metastatic lung cancer tumor response: A real-world study. Cell Rep. Med. 2023;4 - PMC - PubMed
    1. Ma H.-C., Zhu Y.-J., Zhou R., Yu Y.-Y., Xiao Z.-Z., Zhang H.-B. Lung cancer organoids, a promising model still with long way to go. Crit. Rev. Oncol. Hematol. 2022;171 - PubMed
    1. Rossi R., De Angelis M.L., Xhelili E., Sette G., Eramo A., De Maria R., Incani U.C., Francescangeli F., Zeuner A. Lung cancer organoids: The rough path to personalized medicine. Cancers (Basel) 2022;14:3703. - PMC - PubMed
    1. Shi R., Radulovich N., Ng C., Liu N., Notsuda H., Cabanero M., Martins-Filho S.N., Raghavan V., Li Q., Mer A.S., et al. Organoid cultures as preclinical models of non-small cell lung cancer. Clin. Cancer Res. 2020;26:1162–1174. - PubMed
    1. Hu Y., Sui X., Song F., Li Y., Li K., Chen Z., Yang F., Chen X., Zhang Y., Wang X., et al. Lung cancer organoids analyzed on microwell arrays predict drug responses of patients within a week. Nat. Commun. 2021;12:2581. - PMC - PubMed

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