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. 2023 May:130:31-37.
doi: 10.1016/j.ijid.2023.02.012. Epub 2023 Feb 21.

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians

Polianna Delfino-Pereira  1 , Magda Carvalho Pires  2 , Virginia Mara Reis Gomes  3 , Matheus Carvalho Alves Nogueira  4 , Maria Clara Pontello Barbosa Lima  5 , Alexandre Vargas Schwarzbold  6 , Amanda de Oliveira Maurílio  7 , Ana Luiza Bahia Alves Scotton  8 , André Soares de Moura Costa  9 , Barbara Lopes Farace  10 , Bruno Mateus de Castro  11 , Christiane Corrêa Rodrigues Cimini  12 , Daniel Vitório Silveira  13 , Daniela Ponce  14 , Elayne Crestani Pereira  15 , Eliane Würdig Roesch  16 , Euler Roberto Fernandes Manenti  17 , Evelin Paola de Almeida Cenci  18 , Fernanda Costa Dos Santos  19 , Fernando Anschau  20 , Fernando Graça Aranha  21 , Frederico Bartolazzi  22 , Guilherme Fagundes Nascimento  23 , Heloisa Reniers Vianna  24 , Joanna d'Arc Lyra Batista  25 , Joice Coutinho de Alvarenga  26 , Juliana da Silva Nogueira Carvalho  27 , Juliana Machado-Rugolo  28 , Karen Brasil Ruschel  29 , Luanna Silva Monteiro Menezes  30 , Luís César de Castro  31 , Luiz Antônio Nasi  32 , Maiara Anschau Floriani  33 , Maíra Dias Souza  34 , Maíra Viana Rego Souza-Silva  35 , Marcelo Carneiro  36 , Maria Aparecida Camargos Bicalho  37 , Mariana Frizzo de Godoy  38 , Milton Henriques Guimarães-Júnior  39 , Patricia Klarmann Ziegelmann  40 , Pedro Ledic Assaf  41 , Petrônio José de Lima Martelli  42 , Renan Goulart Finger  43 , Saionara Cristina Francisco  44 , Silvia Ferreira Araújo  45 , Talita Fischer Oliveira  46 , Thainara Conceição de Oliveira  47 , Thalita Martins Lage  48 , Vanessa Muller  49 , Yuri Carlotto Ramires  50 , Teresa Cristina de Abreu Ferrari  51 , Milena Soriano Marcolino  52
Affiliations

Clinical characteristics and outcomes of hospital-manifested COVID-19 among Brazilians

Polianna Delfino-Pereira et al. Int J Infect Dis. 2023 May.

Abstract

Objectives: To analyze the clinical characteristics and outcomes of admitted patients with the hospital- versus community-manifested COVID-19 and to evaluate the risk factors related to mortality in the first population.

Methods: This retrospective cohort included consecutive adult patients with COVID-19, hospitalized between March and September 2020. The demographic data, clinical characteristics, and outcomes were extracted from medical records. Patients with hospital-manifested COVID-19 (study group) and those with community-manifested COVID-19 (control group) were matched by the propensity score model. Logistic regression models were used to verify the risk factors for mortality in the study group.

Results: Among 7,710 hospitalized patients who had COVID-19, 7.2% developed symptoms while admitted for other reasons. Patients with hospital-manifested COVID-19 had a higher prevalence of cancer (19.2% vs 10.8%) and alcoholism (8.8% vs 2.8%) than patients with community-manifested COVID-19 and also had a higher rate of intensive care unit requirement (45.1% vs 35.2%), sepsis (23.8% vs 14.5%), and death (35.8% vs 22.5%) (P <0.05 for all). The factors independently associated with increased mortality in the study group were increasing age, male sex, number of comorbidities, and cancer.

Conclusion: Hospital-manifested COVID-19 was associated with increased mortality. Increasing age, male sex, number of comorbidities, and cancer were independent predictors of mortality among those with hospital-manifested COVID-19 disease.

Keywords: COVID-19; Clinical characteristics; Hospital-manifested infection; In-hospital mortality; Outcomes; Risk factors.

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Conflict of interest statement

Declaration of competing interest The authors have no competing interests to declare.

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Supplementary concepts