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Comment
. 2023 Feb 22;8(1):77.
doi: 10.1038/s41392-023-01357-z.

Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy

Songtao Du  1   2 , Furong Zeng  3 , Guangtong Deng  4
Affiliations
Comment

Tumor neutrophils ferroptosis: a targetable immunosuppressive mechanism for cancer immunotherapy

Songtao Du et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Ferroptosis of PMN-MDSCs causes immune suppression in cancer. Spontaneous ferroptosis of PMN-MDSCs in the tumor microenvironment triggers the secretion of PGE2 and the release of oxidized phospholipids, rendering them more immunosuppressive through influencing the activity of CD8+ T cells and tumor-associated macrophages. AA arachidonic acid, ACSL4 acyl-coenzyme A synthetase long-chain family member 4, Alox12/15 arachidonate 12/15-lipoxygenase, GPX4 glutathione peroxidase 4, PE phosphatidylethanolamine, MPO myeloperoxidase, PGE2 prostaglandin E2, PMN-MDSCs pathologically activated neutrophils termed myeloid-derived suppressor cells, TAM tumor-associated macrophage. The images were created with BioRender.com
See this image and copyright information in PMC

Comment on

  • Ferroptosis of tumour neutrophils causes immune suppression in cancer.
    Kim R, Hashimoto A, Markosyan N, Tyurin VA, Tyurina YY, Kar G, Fu S, Sehgal M, Garcia-Gerique L, Kossenkov A, Gebregziabher BA, Tobias JW, Hicks K, Halpin RA, Cvetesic N, Deng H, Donthireddy L, Greenberg A, Nam B, Vonderheide RH, Nefedova Y, Kagan VE, Gabrilovich DI. Kim R, et al. Nature. 2022 Dec;612(7939):338-346. doi: 10.1038/s41586-022-05443-0. Epub 2022 Nov 16. Nature. 2022. PMID: 36385526 Free PMC article.

References

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