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Meta-Analysis
. 2023 Feb 13:2023:2606854.
doi: 10.1155/2023/2606854. eCollection 2023.

A Systematic Review and Meta-Analysis of the Relationship between Receiving the Flu Vaccine with Acute Cerebrovascular Accident and Its Hospitalization in the Elderly

Nilay Rezaei Tavabe  1 , Soleiman Kheiri  1 , Mohsen Dehghani  2 , Abdollah Mohammadian-Hafshejani  3
Affiliations
Meta-Analysis

A Systematic Review and Meta-Analysis of the Relationship between Receiving the Flu Vaccine with Acute Cerebrovascular Accident and Its Hospitalization in the Elderly

Nilay Rezaei Tavabe et al. Biomed Res Int. .

Abstract

Background and aims: In recent years, various studies have been conducted worldwide to investigate the relationship between receiving the flu vaccine with acute cerebrovascular accident or stroke and its hospitalization in the elderly; however, the results of these studies are contradictory. Therefore, this study was aimed at investigating the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly.

Methods: This study is a systematic review and meta-analysis of studies examining the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly during the years 1980 to 2021 which have been published in ISI Web of Science, Scopus PubMed, Cochrane, Science Direct, Google Scholar, and Embase. All analyses were performed by Stata 15, and the significance level in this study was considered <0.05.

Results: In the systematic search, 3088 articles were retrieved, considering the study criteria; finally, 14 studies were included in the meta-analysis. Based on the results of the meta-analysis, the odds ratio (OR) of occurrence and hospitalization of stroke compared to the nonvaccinated group in vaccine recipients is equal to 0.84 (95% confidence interval (CI): 0.78-0.90, P value ≤ 0.001). Publication bias was not observed in this study (P value = 0.101).

Conclusion: Getting the flu vaccine can reduce the risk of occurrence and hospitalization of stroke in the elderly by 16% (10%-22%). Therefore, receiving this vaccine as a preventive intervention for stroke in the elderly may be promising.

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Conflict of interest statement

There is no conflict of interest in this study.

Figures

Figure 1
Figure 1
Diagram of selected studies for meta-analysis.
Figure 2
Figure 2
Forest plot of the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly.
Figure 3
Figure 3
Sensitivity analysis for the assessment of the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly.
Figure 4
Figure 4
Galbraith plot showing heterogeneity in meta-analysis studies.
Figure 5
Figure 5
Funnel plot for evaluation of publication bias in investigating the relationship between receiving the flu vaccine with stroke and its hospitalization in the elderly.
See this image and copyright information in PMC

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