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. 2023 Feb 6:13:1064815.
doi: 10.3389/fonc.2023.1064815. eCollection 2023.

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Xin Wu  1 , Shiwei Ma  2 , Zhongguang Wu  3 , Qiangqiang Zhao  4
Affiliations

Global scientific trends on matrix metalloproteinase and osteosarcoma: A bibliometric and visualized analysis

Xin Wu et al. Front Oncol. .

Abstract

Objective: This study aimed to identify author, country, institutional, and journal collaborations and their impacts, assess the knowledge base, identify existing trends, and uncover emerging topics related to the role of Metalloproteinase in osteosarcoma.

Methods: 945 Articles and reviews associated with the role of Metalloproteinase in osteosarcoma were obtained from the WoSCC and analyzed by Citespace and Vosviewer.

Results: The main aspects of research on the role of MMP in OS are invasion and metastasis. The latest hotspots were found to be the mechanism of MMP promoting invasion and metastasis, lung metastasis, and antitumor activity. Notably, invasion, metastasis, and antitumor activity were potentially turning points in the MMP-OS field. In the future, the primary research hotspot in the field of MMP-OS may be to study the mechanism, explore their role in the OS lung metastasis, and determine their role in the cancer therapy process.

Conclusion: This study thus offers a comprehensive overview of the MMP-OS-related field using bibliometrics and visual methods, which will provide a valuable reference for researchers interested in the field of MMP-OS.

Keywords: bibliometric; matrix metalloproteinase; osteosarcoma; prognoses; pulmonary metastasis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The emerging hot spot of the role of Metalloproteinase in OS may be to promote invasion and metastasis.
Figure 2
Figure 2
(A) Annual publication number and citation frequency of MMP-OS related studies. (B) Composition ratio of the top 10 countries by publication number.
Figure 3
Figure 3
The dual-map overlay of journals related to MMP-OS research Notes: The citing journals were at left, the cited journals were on the right, and the colored path represents citation relationship.
Figure 4
Figure 4
The co-occurrence map of (A) countries/regions and (B) institutions in MMP-OS research (T≥19). The size of node reflects the co-occurrence frequencies, and the links indicate the co-occurrence relationships. The color of node and line represents different years, colors vary from purple to red as time goes from1999 to 2022; and node with purple round means high betweenness centrality (>0.1).
Figure 5
Figure 5
The density map of authors in MMP-OS research (T≥5). The size of word, the size of round, and the opacity of yellow is positively related to the publication frequency.
Figure 6
Figure 6
The co-occurrence map of co-cited authors in MMP-OS research (T≥40). the link indicate the co-occurrence relationship between authors, and the same color of node represent the same cluster.
Figure 7
Figure 7
The density map of terms in MMP-OS research (T≥6), The size of word, the size of round, and the opacity of red is positively related to the co-occurrence frequency.
Figure 8
Figure 8
keyword co-occurrence network and clusters in MMP-OS research (T≥6, contains 72 items, 3 clusters and 3708 links; maxlines = 1000.). The size of node and word reflects the co-occurrence frequencies, the link indicate the co-occurrence relationship, and the same color of node represent the same cluster.
Figure 9
Figure 9
Keywords with strongest citation burst’s view of MMP-OS research.
Figure 10
Figure 10
Top 20 references with the strongest citation bursts (sorted by the strength). The Blue bars mean the reference had been published; the red bars mean citation burstiness.
Figure 11
Figure 11
The dual-map overlay of journals related to top 100 most cited references in MMP-OS research. The citing journals were at left, the cited journals were on the right, and the colored path represents citation relationship.
Figure 12
Figure 12
Country-to-country relations of Top 100 Most-cited Articles.
Figure 13
Figure 13
keyword co-occurrence network and clusters in MMP-OS research (T≥2, contains 37 items, 3 clusters and 788 links; maxlines = 1000.). The size of node and word reflects the co-occurrence frequencies, the link indicate the co-occurrence relationship, and the same color of node represent the same cluster.
Figure 14
Figure 14
Association between the MMPs expression and the prognosis of OS.
See this image and copyright information in PMC

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