Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Feb 5;16(2):100748.
doi: 10.1016/j.waojou.2023.100748. eCollection 2023 Feb.

Latin American anaphylaxis registry

Edgardo J Jares  1 , Victoria Cardona  2 , R Maximiliano Gómez  3 , Jonathan A Bernstein  4 , Nelson A Rosario Filho  5 , Ivan Cherrez-Ojeda  6 , Luis Felipe Ensina  7 , Alicia De Falco  8 , María C Díaz  9 , Pierre A Chávez Vereau  10 , Mara M Rocha Felix  11 , Jorge Lavrut  9 , Oscar I Moreno Laflor  12 , Patricia Latour Staffeld  13 , Pedro Piraino  14 , Perla Alacaraz Duarte  15 , Juan C Ivancevich  16 , Fabian Dabove  17 , Pedro Giavina-Bianchi  18 , Iván O Tinoco Moran  19 , Fabiana A Nunes Oliviera  20 , Silvana Monsell  21 , María V Souza  9 , Alfonso M Cepeda  22 , Pablo D Slullitel  23 , Blanca M Morfin-Maciel  24
Affiliations

Latin American anaphylaxis registry

Edgardo J Jares et al. World Allergy Organ J. .

Abstract

Background: Recent data about clinical features, triggers and management of anaphylaxis in Latin America is lacking.

Objective: To provide updated and extended data on anaphylaxis in this region.

Method: An online questionnaire was used, with 67 allergy units involved from 12 Latin-American countries and Spain. Among data recorded, demographic information, clinical features, severity, triggering agents, and treatment were received.

Results: Eight hundred and seventeen anaphylactic reactions were recorded. No difference in severity, regardless of pre-existing allergy or asthma history was found. Drug induced anaphylaxis (DIA) was most frequent (40.6%), followed by food induced anaphylaxis (FIA) (32.9%) and venom induced anaphylaxis (VIA) (12%). FIA and VIA were more common in children-adolescents. Non-steroidal anti-inflammatory drugs (NSAIDs) and beta-lactam antibiotics (BLA) were the most frequent drugs involved. Milk (61.1% of FIA) and egg (15.4% of FIA) in children, and shellfish (25.5% of FIA), fresh fruits (14.2% of FIA), and fish (11.3% of FIA) in adults were the most common FIA triggers. Fire ants were the most frequent insect triggers, and they induced more severe reactions than triggers of FIA and DIA (p < 0.0001). Epinephrine was used in 43.8% of anaphylaxis episodes. After Emergency Department treatment, epinephrine was prescribed to 13% of patients.

Conclusions: Drugs (NSAIDs and BLA), foods (milk and egg in children and shellfish, fruits and fish in adults) and fire ants were the most common inducers of anaphylaxis. Epinephrine was used in less than half of the episodes emphasizing the urgent need to improve dissemination and implementation of anaphylaxis guidelines.

Keywords: Anaphylaxis; Food hypersensitivity; Insect venom hypersensitivity; Latin America; Medication hypersensitivity.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Anaphylaxis triggers in children/adolescents and adults.
Fig. 2
Fig. 2
Anaphylaxis triggers by age groups.
Fig. 3
Fig. 3
Pharmacological treatment Abbreviations: IV: Intravenous, SC: Subcutaneous, IM: Intramuscular.
See this image and copyright information in PMC

References

    1. Simons E., Ardusso L., Bilo M., et al. International consensus on (ICON) anaphylaxis. World Allergy Organ J. 2014;7:9. doi: 10.1186/1939-4551-7-9. - DOI - PMC - PubMed
    1. Sampson H.A., Muñoz-Furlong A., Campbell R.L., et al. Second symposium on the definition and management of anaphylaxis: summary report - second National Institute of allergy and infectious disease/food allergy and anaphylaxis network symposium. J Allergy Clin Immunol. 2006;117:391–397. - PubMed
    1. Muraro A., Roberts G., Worm M., et al. Anaphylaxis: guidelines from the European Academy of allergy and clinical Immunology. Allergy. 2014;69:1026–1045. 434 10.1111/all.12437. - PubMed
    1. Muraro A., Worm M., Alviani C., et al. EAACI guidelines: anaphylaxis (2021 update) Allergy. 2022 Feb;77(2):357–377. doi: 10.1111/all.15032. Epub 2021 Sep. 1. - DOI - PubMed
    1. Cardona V., Álvarez-Perea A., Ansotegui-Zubeldia I.J., et al. Clinical practice guide for anaphylaxis in Latin America (Galaxia-Latam) Rev Alerg Mex. 2019;66(Suppl 2):1–39. doi: 10.29262/ram.v66i6.588. - DOI - PubMed

LinkOut - more resources