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Case Reports
. 2023 Feb 2:13:1072336.
doi: 10.3389/fonc.2023.1072336. eCollection 2023.

Case report: First case of early adenoid cystic carcinoma and squamous cell carcinoma collision cancer treated by endoscopic submucosal dissection

Zheng Liang  1 , Yongqiu Wei  1 , Peng Li  1 , Rui Xu  2 , Qiaozhi Zhou  1 , Shutian Zhang  1
Affiliations
Case Reports

Case report: First case of early adenoid cystic carcinoma and squamous cell carcinoma collision cancer treated by endoscopic submucosal dissection

Zheng Liang et al. Front Oncol. .

Abstract

Background: Collision cancer, a rare tumor, rarely occurs in the esophagus. Most reported cases of esophageal collision cancers are advanced cancers that can only be treated with surgery or palliative chemoradiotherapy. Here, we report a rare case of collisional squamous cell carcinoma (SqCC) and adenoid cystic carcinoma (AdCC) that was detected in the early stages by endoscopy.

Case summary: A 66-year-old man presented with retrosternal pain after swallowing and underwent endoscopy. Pathological biopsy showed high-grade squamous intraepithelial neoplasia. The lesion was removed by endoscopic submucosal dissection (ESD) after magnification and endoscopic ultrasonography. Postoperative pathology proved that the lesion was collision cancer comprising SqCC and AdCC. After six months of postoperative follow-up, there was no recurrence of esophageal cancer.

Conclusions: We provided a case report related to the diagnosis and treatment of esophageal collision cancer, especially early collision cancer. More research is needed to provide insights into the management of collision cancers.

Keywords: collision cancer; early esophageal cancer; endoscopic submucosal dissection; esophageal adenoid cystic carcinoma; esophageal squamous cell carcinoma.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) A type 0-IIa lesion under white light endoscopy, approximately 1*1 cm in size, located in the middle of the esophagus and 28-29 cm from the incisors; (B) Esophageal lesion under blue laser endoscopy; (C) The background staining was positive under blue laser imaging magnifying endoscope. The JES type was B1, and the AVA type was small AVA. (D) Five-layer structure of the esophageal wall at the lesion was clear, and the mucosal layer was slightly thickened under ultrasound endoscope. (E) Esophageal wound after ESD. (F) An 18*14 mm esophageal mucosal tissue.
Figure 2
Figure 2
Translucent observation of the lesion and microscopic appearance of the lesion.
Figure 3
Figure 3
(A) Full view of collision carcinoma; (B) Area of collision between SqCC (up) and AdCC (down); (C) Area of SqCC; (D) Area of AdCC; (E) Immunohistochemical staining of AdCC (CD117); (F) Immunohistochemical staining of AdCC (S-100).
See this image and copyright information in PMC

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References

    1. Coca-Pelaz A, Triantafyllou A, Devaney KO, Rinaldo A, Takes RP, Ferlito A. Collision tumors of the larynx: A critical review. Am J Otolaryngol (2016) 37:365–8. doi: 10.1016/j.amjoto.2016.02.010 - DOI - PubMed
    1. Syed S, Karambizi DI, Baker A, Groh DM, Toms SA. A comparative report on intracranial tumor-to-Tumor metastasis and collision tumors. World Neurosurg (2018) 116:454–463.e2. doi: 10.1016/j.wneu.2018.04.109 - DOI - PubMed
    1. Bhangoo MS, Zhou JY, Ali SM, Madison R, Schrock AB, Costantini C. Objective response to mTOR inhibition in a metastatic collision tumor of the liver composed of melanoma and adenocarcinoma with TSC1 loss: A case report. BMC Cancer (2017) 17:197. doi: 10.1186/s12885-017-3167-y - DOI - PMC - PubMed
    1. Montironi R, Santoni M, Goteri G, Mazzucchelli R, Lopez-Beltran A, Cheng L, et al. . Pseudocarcinomatous hyperplasia associated with primary lymphoma in the urinary bladder: A case report. Hum Pathol (2015) 46:1040–4. doi: 10.1016/j.humpath.2015.03.004 - DOI - PubMed
    1. Choi GH, Ann SY, Lee SI, Kim SB, Song IH. Collision tumor of hepatocellular carcinoma and neuroendocrine carcinoma involving the liver: Case report and review of the literature. World J Gastroenterol (2016) 22:9229–34. doi: 10.3748/wjg.v22.i41.9229 - DOI - PMC - PubMed

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