Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 2:13:1052012.
doi: 10.3389/fonc.2023.1052012. eCollection 2023.

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Shan Xiao  1 , Huan Gu  2 , Li Deng  1 , Xiongtao Yang  2 , Dan Qiao  2 , Xudong Zhang  3 , Tian Zhang  2 , Tao Yu  1   2
Affiliations
Review

Relationship between NUDT21 mediated alternative polyadenylation process and tumor

Shan Xiao et al. Front Oncol. .

Abstract

Alternative polyadenylation (APA) is a molecular process that generates diversity at the 3' end of RNA polymerase II transcripts from over 60% of human genes. APA and microRNA regulation are both mechanisms of post-transcriptional regulation of gene expression. As a key molecular mechanism, Alternative polyadenylation often results in mRNA isoforms with the same coding sequence but different lengths of 3' UTRs, while microRNAs regulate gene expression by binding to specific mRNA 3' UTRs. Nudix Hydrolase 21 (NUDT21) is a crucial mediator involved in alternative polyadenylation (APA). Different studies have reported a dual role of NUDT21 in cancer (both oncogenic and tumor suppressor). The present review focuses on the functions of APA, miRNA and their interaction and roles in development of different types of tumors.NUDT21 mediated 3' UTR-APA changes can be used to generate specific signatures that can be used as potential biomarkers in development and disease. Due to the emerging role of NUDT21 as a regulator of the aforementioned RNA processing events, modulation of NUDT21 levels may be a novel viable therapeutic approach.

Keywords: NUDT21; alternative polyadenylation; microRNA; therapy; tumor.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Sung H, Ferlay J, Siegel R, Laversanne M, Soerjomataram I, Jemal A, et al. . Global cancer statistics 2020, GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin (2021) 71:209–49. doi: 10.3322/caac.21660 - DOI - PubMed
    1. Tan S, Li H, Zhang W, Shao Y, Liu Y, Guan H, et al. . NUDT21 negatively regulates PSMB2 and CXXC5 by alternative polyadenylation and contributes to hepatocellular carcinoma suppression. Oncogene (2018) 37:4887–900. doi: 10.1038/s41388-018-0280-6 - DOI - PubMed
    1. Edmonds M, Abrams R. Polynucleotide biosynthesis, formation of a sequence of adenylate units from adenosine triphosphate by an enzyme from thymus nuclei. J Biol Chem (1960) 235:1142–9. doi: 10.1016/S0021-9258(18)69494-3 - DOI - PubMed
    1. Logan J, Falck-Pedersen E, Darnell J, Jr, Shenk T. A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc Natl Acad Sci United States America (1987) 84:8306–10. doi: 10.1073/pnas.84.23.8306 - DOI - PMC - PubMed
    1. Whitelaw E, Proudfoot N. Alpha-thalassaemia caused by a poly(A) site mutation reveals that transcriptional termination is linked to 3’ end processing in the human alpha 2 globin gene. EMBO J (1986) 5:2915–22. doi: 10.1002/j.1460-2075.1986.tb04587.x - DOI - PMC - PubMed