Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jan;35(1):39-45.
doi: 10.1016/j.sdentj.2022.12.003. Epub 2022 Dec 16.

Melanotic neuroectodermal tumor of infancy: A narrative review of dental aspects

Affiliations
Review

Melanotic neuroectodermal tumor of infancy: A narrative review of dental aspects

Bader Fatani et al. Saudi Dent J. 2023 Jan.

Abstract

Melanotic neuroectodermal tumors of infancy (MNTI) are a rare type of benign tumor that affects the head and neck region. MNTI represents (68-80%) of the tumors in the maxillary region. This tumor is usually located in the alveolar crest, skull, mandible, and brain. Although this tumor is considered benign, it can grow rapidly, with a high risk of recurrence and interference with functions of infancy, such as feeding and breathing. It is also frequently harmful to the surrounding soft and hard tissues or adjacent sensitive vital structures. This study aimed to review the pathological, clinical presentation, and treatment of melanotic neuroectodermal tumors in infancy and the role of dentists in these cases.

Keywords: Complication; Dental; Infancy; MNTI; Treatment.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Image showing MNTI that resembles a small round blue cell tumor (Soles et al. 2018).
Fig. 2
Fig. 2
Image showing swelling in the pre-maxillary region (Chaudhary et al. 2014).
Fig. 3
Fig. 3
(A). The horizontal position of spiral CT, the low-density image of the anterior left maxilla, and the bone destruction (arrow). (B). The horizontal position of spiral CT showed multicentric growth in the lesion (Wang et al. 2022).
Fig. 4
Fig. 4
Image showing removed lesion with deciduous central incisor (Chaudhary et al. 2014).
Fig. 5
Fig. 5
2 years post-excision (Fakuade et al. 2017).

References

    1. Agrawal A., Joshi J., Agrawal D., Kumar P., Modi B. Oral melanotic neuroectodermal tumor of infancy: management of a case affecting the maxilla. J. Indian Soc. Pedodontics Prevent. Dent. 2020;38(3):319. - PubMed
    1. Almomani M.H., Rentea R.M. StatPearls Publishing; In StatPearls: 2022. Melanotic Neuroectodermal Tumor Of Infancy. - PubMed
    1. Atarbashi-Moghadam S., Lotfi A., Moshref M., Atarbashi-Moghadam F. Melanotic neuroectodermal tumor of infancy, a rapidly growing maxillary alveolar mass: a case report. J. Dent. (Shiraz, Iran) 2020;21(1):77–80. doi: 10.30476/DENTJODS.2019.44910. - DOI - PMC - PubMed
    1. Béogo R., Nikiéma Z., Traoré S.S., Bouletreau P. Maxillary melanotic neuroectodermal tumor of infancy management: is conservative surgery the best approach? J. Craniofac. Surg. 2013;24(4):e338–e340. doi: 10.1097/SCS.0b013e31828a7c4c. - DOI - PubMed
    1. Chaudhary S., Manuja N., Ravishankar C.T., Sinha A., Vijayran M., Singh M. Oral melanotic neuroectodermal tumor of infancy. J. Indian Soc. Pedodontics Prevent. Dent. 2014;32(1):71. - PubMed

LinkOut - more resources