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. 2023 Jan 27;25(3):96.
doi: 10.3892/ol.2023.13682. eCollection 2023 Mar.

Superficial soft tissue sarcomas: 10‑year survival outcomes

Maria Tolia  1 , Areti Gkantaifi  2 , Larry Hayward  3 , Girish Gupta  4 , Anastasios Kyriazoglou  5 , Davide Mauri  6 , Ioanna Nixon  7
Affiliations

Superficial soft tissue sarcomas: 10‑year survival outcomes

Maria Tolia et al. Oncol Lett. .

Abstract

Cutaneous sarcomas comprise a broad group of rare, heterogeneous mesenchymal tumours. The present report describes a single centre experience regarding the management and the outcomes of patients with superficial soft tissue sarcomas (SSTS). Key prognostic factors in predicting overall survival (OS) and local relapse-free survival were determined. Data from 66 patients with SSTS treated surgically within Edinburgh and Lothian were collected in the context of a service evaluation. Patient demographics, tumour specifics and treatment, as well as 5-year OS and local recurrence, were analysed. Kaplan-Meier analysis was applied for survival curves, and mortality rate estimation and Cox regression were used to establish independent predictors. The mean estimated OS time was 57.2 months, with a 95% CI between 55.0 and 59.5 months. The median OS time could not be estimated because there is no time point during which the survival function has a value <50%. The death risk for a person with SSTS was increased by 7.3% (odds ratio, 1.073; 95% CI, 1.012-1.138) for every additional year of life. The estimated mean local relapse time was 58.5 months, with a 95% CI between 56 and 61 months. The median local relapse time could not be estimated since there is no time point during which the local recurrence function has a value <50%. In conclusion, out of all independent variables considered, none could statistically significantly explicate local relapse recurrence time. It is important that these rare tumours are treated in the context of a multidisciplinary team with consensus guidelines to assist decision-making.

Keywords: outcomes; sarcomas; soft tissue; superficial; survival.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1.
Figure 1.
Overall survival function (survival curve using the Kaplan-Meier method).
Figure 2.
Figure 2.
Survival function at mean of covariates (in months).
Figure 3.
Figure 3.
Local relapse-free survival function (in months).
Figure 4.
Figure 4.
Local relapse-free survival function at mean of covariates (in months).
See this image and copyright information in PMC

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