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. 2022 Oct-Dec;37(4):400-401.
doi: 10.4103/ijnm.ijnm_107_22. Epub 2022 Dec 2.

Tc-99m Sulfur Colloid Scintigraphy in Differentiating Fat Sparing from Lymphomatous Involvement of Liver-Old Wine in New Bottle

Lakshman Aridhasan Meenakshi  1 , Brinda Ravichandran  1 , Vishnukumar Rajaraman  1 , Nandini Pandit  1
Affiliations

Tc-99m Sulfur Colloid Scintigraphy in Differentiating Fat Sparing from Lymphomatous Involvement of Liver-Old Wine in New Bottle

Lakshman Aridhasan Meenakshi et al. Indian J Nucl Med. 2022 Oct-Dec.

Abstract

Hepatic mass lesions and focal fat sparing in a fatty liver may be difficult to differentiate on contrast-enhanced computed tomography (CT) imaging and F-18-fluorodeoxyglucose positron emission tomography/CT. Tc-99m Sulfur colloid (SC) scintigraphy has been used in the assessment of solid hepatic masses. Liver metastases will appear as focal photopenic defects due to the loss of Kupffer cell function. However, focal fatty infiltration or fat sparing of the liver does not affect Kupffer cell function and thereby leading to normal tracer uptake. Despite several advances in imaging modalities, Tc-99m SC scintigraphy is still a reliable armamentarium in the characterization of hepatic mass lesions.

Keywords: F-18 Fluorodeoxyglucose positron emission tomography/computed tomography; Hodgkin's lymphoma; Tc-99m sulfur colloid scintigraphy.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
(a) image showing multiple foci of FDG uptake in the abdominal lymph nodes along with multiple foci of increased FDG uptake in the liver (black arrows). Axial fused F-18 FDG PET/CT (b and c) and CECT (d and e) images showing increased focal FDG uptake over hyperdense lesions in Segments IVa and V in the background of diffuse fatty changes. Tc-99m SC SPECT (f and g) images showing areas of photopenia over the corresponding regions in the liver. CT: Computed tomography, FDG: Fluorodeoxyglucose, F-18 FDG PET/CT: F-18 FDG positron emission tomography/CT, SPECT: Single-photon emission CT, SC: Sulfur colloid
See this image and copyright information in PMC

References

    1. Hamer OW, Aguirre DA, Casola G, Lavine JE, Woenckhaus M, Sirlin CB. Fatty liver: Imaging patterns and pitfalls. Radiographics. 2006;26:1637–53. - PubMed
    1. Harisankar CN. Focal fat sparing of the liver: A nonmalignant cause of focal FDG uptake on FDG PET/CT. Clin Nucl Med. 2014;39:e359–61. - PubMed
    1. Kinnard MF, Alavi A, Rubin RA, Lichtenstein GR. Nuclear imaging of solid hepatic masses. Semin Roentgenol. 1995;30:375–95. - PubMed
    1. Alderson PO, Adams DF, McNeil BJ, Sanders R, Siegelman SS, Finberg HJ, et al. Computed tomography, ultrasound, and scintigraphy of the liver in patients with colon or breast carcinoma: A prospective comparison. Radiology. 1983;149:225–30. - PubMed
    1. Lisbona R, Mishkin S, Derbekyan V, Novales-Diaz JA, Roy A, Sanders L. Role of scintigraphy in focally abnormal sonograms of fatty livers. J Nucl Med. 1988;29:1050–6. - PubMed

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