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. 2023 Feb 2:14:1063548.
doi: 10.3389/fimmu.2023.1063548. eCollection 2023.

Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis

Liu Bo  1 , Liu Tianming  1 , Fan Fengliang  1 , Liang Wenping  1 , Han Jinzuo  1 , Xue Dongbo  1 , Ma Biao  1 , Sun Haijun  1
Affiliations

Global trends of Vaccinia oncolytic virus therapy over the past two decades: Bibliometric and visual analysis

Liu Bo et al. Front Immunol. .

Abstract

Background: In recent years, the vaccinia oncolytic virus has entered the clinical trial stage of examination and shown good progress. It has many advantages, such as good safety, high oncolytic efficiency, and the regulation ability of the tumor microenvironment, and is expected to be successfully used in the clinical treatment of tumors in the future. However, no bibliometric analysis has so far been performed that generalizes horizontally across this field. Therefore, this study aims to assess the research status and trends in this field from a global perspective to help guide future research priorities.

Methods: In this study, the literature related to vaccinia oncolytic virus published in English on Web of Science from 2002 to 2022 was retrieved, and the bibliometric indicators were analyzed using the Histcite. Pro 2.0 tool, while VOSviewer was used to visualize the research trends and hotspots in this field.

Results: In total, 408 related studies were included. In the past 20 years, the number of related publications in this field has increased year by year, and breakthroughs were made in this field in 2008 and 2013. The research has grown rapidly since 2008, and will likely continue to expand in the years to come. The United States plays a leading role in this area. "MOLECULAR THERAPY-ONCOLYTICS", "MOLECULAR THERAPY" and "JOURNAL OF TRANSLATIONAL MEDICINE" are core journals that publish high-quality literature on the latest advances in the field. Some authors with numerous high-quality publications include Bell JC and Szalay AA. At present, the research hotspot in this field focus on the clinical application of vaccinia oncolytic virus.

Conclusion: Overall, the number of vaccinia oncolytic virus-related studies is growing rapidly, in relation to which the United States is the most influential country. The clinical application of vaccinia oncolytic virus will affect the crucial development of future research.

Keywords: VOSviewer; bibliometric; knowledge map; oncolytic virus; tumor.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The number of publications and LCS by year over the past 20 years.
Figure 2
Figure 2
Contributions of countries. (A) The top 10 countries with the greatest numbers of publications. (B) The top 10 countries with the greatest numbers of LCS. (C) The top 10 countries with the highest H-index scores.
Figure 3
Figure 3
Contributions of scholars. (A) The top 10 scholars in terms of the total number of published articles. (B) The top 10 scholars in terms of the total number of LCS. (C) The top 10 scholars in terms of the total number of LCSx. (D) The top 10 scholars with the greatest H-index scores.
Figure 4
Figure 4
Contributions of institution. (A) The top 10 institutions in terms of total publication volume. (B) The top 10 institutions in terms of total LCS. (C) The top 10 institutions with the largest H-index scores.
Figure 5
Figure 5
Published journals. (A) The top 10 journals with the greatest numbers of publications. (B) The top 10 journals with the most LCS. (C) The top 10 journals with the greatest H-index scores.
Figure 6
Figure 6
Research status and development trend. (A) The 47 keywords that arose more than 16 times were divided into three clusters, represented by different colors. The sizes of the nodes represent the frequency of occurrences. (B) Visualization of keywords according to the average publication year. Keywords in yellow appeared later than those in blue (color figure online).
Figure 7
Figure 7
Co-cited references and co-cited scholars. (A) Network map of co-cited references. Of the 10,812 references, 44 (classified into three clusters) had been cited at least 25 times. (B) Network map of co-cited scholars. Of the 8,405 scholars, 65 (classified into three clusters) had been cited at least 25 times.
Figure 8
Figure 8
Co-authoring relationship. (A) Network map of scholars’ co-authoring relationships. Of the1,765 scholars, 129 showed a co-authoring relationship. (B) Network map of institutional co-authoring relationship. Of the 5,476 institutions, 50 showed a co-authoring relationship.
Figure 9
Figure 9
Co-authoring relationship Network map of countries’ co-authoring relationships. In total, 14 countries showed a co-authoring relationship.
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