Published Erratum
doi: 10.3389/fcell.2023.1141334.
eCollection 2023.
Corrigendum: Deepening the understanding of CNVs on chromosome 15q11-13 by using hiPSCs: An overview
Affiliations
- PMID: 36819100
- PMCID: PMC9930142
- DOI: 10.3389/fcell.2023.1141334
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Published Erratum
Corrigendum: Deepening the understanding of CNVs on chromosome 15q11-13 by using hiPSCs: An overview
Front Cell Dev Biol.
.
Abstract
[This corrects the article DOI: 10.3389/fcell.2022.1107881.].
Keywords: 15q11-13; CHRNA7; CNV; copy number variation; neurodevelopmental disorders; neuropsychiatric disorders; nicotinic acetylcholine receptor.
Copyright © 2023 Giovenale, Ruotolo, Soriano, Turco, Rotundo, Casamassa, D’Anzi, Vescovi and Rosati.
Figures
Chromosome 15q13.3 and hiPSCs derived from individuals with CNV. Graphic representation of chromosomal region 15q13.3 showing BreakPoint regions BP3, BP4 and BP5 and the extensions the microdeletions and microduplications present in the hiPSCs in the published studies.
An insight into molecular effects of CNV 15q13.3. Cells carrying CNV duplications show decreased calcium flux associated with the α7 receptor, downregulation of JAK2-PI3K pathway, decreased assembly and trafficking of nAchRs, and ER stress. Cells carrying CNV deletions exhibit decreased α7nAchRs calcium flux and downregulation of JAK2-PI3K pathway.
Erratum for
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Deepening the understanding of CNVs on chromosome 15q11-13 by using hiPSCs: An overview.Front Cell Dev Biol. 2023 Jan 6;10:1107881. doi: 10.3389/fcell.2022.1107881. eCollection 2022. Front Cell Dev Biol. 2023. PMID: 36684422 Free PMC article. Review.
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