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. 2023 Jan 9;20(12):1013-1018.
doi: 10.18502/ijrm.v20i12.12562. eCollection 2022 Dec.

The effect of Nifedipine on embryo transfer outcomes: A randomized clinical trial

Masoomeh Nataj Majd  1 , Ashraf Moini  2   3   4 , Saghar Samimi Sadeh  5 , Ehsan Bastanhagh  5
Affiliations

The effect of Nifedipine on embryo transfer outcomes: A randomized clinical trial

Masoomeh Nataj Majd et al. Int J Reprod Biomed. .

Abstract

Background: Endometrial receptivity is crucial for embryo implantation, and excessive uterine contraction reduces success. Nifedipine which is a calcium channel blocker, could decrease uterine contraction and improve pregnancy outcomes.

Objective: This study aimed to assess the effect of Nifedipine before embryo transfer on the pregnancy outcome in women undergoing in vitro fertilization (IVF) in a tertiary center in Iran.

Materials and methods: 150 women who were candidates for IVF were randomly assigned into 2 groups: group 1 received 20 mg Nifedipine 30 min before embryo transfer, and group 2 received no intervention. Blood pressure of the participants was monitored every 10 min for 1 hr under the supervision of an anesthesiologist. Finally, implantation rate and chemical and clinical pregnancy rates were compared between groups.

Results: At the end of the study, 140 participants were included in the final analyses. No significant difference was observed in clinical pregnancy rates between groups (20% vs. 22%, p = 0.51).

Conclusion: Nifedipine administration before embryo transfer does not improve the implantation and clinical pregnancy rates in women undergoing IVF.

Keywords: Contraction.; In vitro fertilization; Uterus; Nifedipine.

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Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
The study CONSORT flowchart.
See this image and copyright information in PMC

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