Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan 9;20(12):1013-1018.
doi: 10.18502/ijrm.v20i12.12562. eCollection 2022 Dec.

The effect of Nifedipine on embryo transfer outcomes: A randomized clinical trial

Masoomeh Nataj Majd  1 , Ashraf Moini  2   3   4 , Saghar Samimi Sadeh  5 , Ehsan Bastanhagh  5
Affiliations

The effect of Nifedipine on embryo transfer outcomes: A randomized clinical trial

Masoomeh Nataj Majd et al. Int J Reprod Biomed. .

Abstract

Background: Endometrial receptivity is crucial for embryo implantation, and excessive uterine contraction reduces success. Nifedipine which is a calcium channel blocker, could decrease uterine contraction and improve pregnancy outcomes.

Objective: This study aimed to assess the effect of Nifedipine before embryo transfer on the pregnancy outcome in women undergoing in vitro fertilization (IVF) in a tertiary center in Iran.

Materials and methods: 150 women who were candidates for IVF were randomly assigned into 2 groups: group 1 received 20 mg Nifedipine 30 min before embryo transfer, and group 2 received no intervention. Blood pressure of the participants was monitored every 10 min for 1 hr under the supervision of an anesthesiologist. Finally, implantation rate and chemical and clinical pregnancy rates were compared between groups.

Results: At the end of the study, 140 participants were included in the final analyses. No significant difference was observed in clinical pregnancy rates between groups (20% vs. 22%, p = 0.51).

Conclusion: Nifedipine administration before embryo transfer does not improve the implantation and clinical pregnancy rates in women undergoing IVF.

Keywords: Contraction.; In vitro fertilization; Uterus; Nifedipine.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest.

Figures

Figure 1
Figure 1
The study CONSORT flowchart.
See this image and copyright information in PMC

References

    1. Davari Tanha F, Mohseni M, Ghajarzadeh M. Sexual function in women with primary and secondary infertility in comparison with controls. Int J Impot Res. 2014;26:132–134. - PubMed
    1. Ng KK, Rozen G, Stewart T, Agresta F, Polyakov A. A double-blinded, randomized, placebo-controlled trial assessing the effects of Nifedipine on embryo transfer: Study protocol. Medicine. 2017;96:e9194. - PMC - PubMed
    1. Enciso M, Aizpurua J, Rodríguez-Estrada B, Jurado I, Ferrández-Rives M, Rodríguez E, et al. The precise determination of the window of implantation significantly improves ART outcomes. Sci Rep. 2021;11:13420. - PMC - PubMed
    1. Günther V, Otte SV, Freytag D, Maass N, Alkatout I. Recurrent implantation failure - an overview of current research. Gynecol Endocrinol. 2021;37:584–590. - PubMed
    1. Waclawik A, Kaczmarek MM, Blitek A, Kaczynski P, Ziecik AJ. Embryo-maternal dialogue during pregnancy establishment and implantation in the pig. Mol Reprod Dev. 2017;84:842–855. - PubMed

LinkOut - more resources