Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb 2:10:1116051.
doi: 10.3389/fnut.2023.1116051. eCollection 2023.

Trends and recent progresses of selenium nanoparticles as novel autophagy regulators for therapeutic development

Dongsheng Chen  1   2 , Hongmei Lu  1 , Yuhe Ma  1   2 , Yuhe Huang  1   2 , Tangxin Zhang  3 , Shuhao Fan  1   2 , Wensen Lin  1   2 , Yifan Huang  1   2 , Hua Jin  1 , Yongdui Ruan  1 , Jun-Fa Xu  1   2 , Jiang Pi  1   2
Affiliations
Review

Trends and recent progresses of selenium nanoparticles as novel autophagy regulators for therapeutic development

Dongsheng Chen et al. Front Nutr. .

Abstract

Autophagy, one of the major intracellular degradation systems, plays an important role in maintaining normal cellular physiological functions and protecting organisms from different diseases. Selenium (Se), an essential trace element, is involved in many metabolic regulatory signaling events and plays a key role in human health. In recent years, selenium nanoparticles (Se NPs) have attracted increasing attentions in biomedical field due to their low toxicity, high bioavailability and high bioactivity. Taking the advantage of their advanced biological activities, Se NPs can be used alone as potential therapeutic agents, or combine with other agents and served as carriers for the development of novel therapeutics. More interestingly, Se NPs have been widely reported to affect autophagy signaling, which therefor allow Se NPs to be used as potential therapeutic agents against different diseases. Here, this review suggested the relationships between Se and autophagy, followed by the trends and recent progresses of Se NPs for autophagy regulation in different diseased conditions. More importantly, this work discussed the roles and potential mechanisms of Se NPs in autophagy regulating, which might enhance our understanding about how Se NPs regulate autophagy for potential disease treatment. This work is expected to promote the potential application of Se NPs as novel autophagy regulators, which might benefit the development of novel autophagy associated therapeutics.

Keywords: autophagy; regulators; selenium; selenium nanoparticles; therapeutics.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Mechanisms for selenium (Se) regulated cellular autophagy.
FIGURE 2
FIGURE 2
Anticancer effects of selenium nanoparticles (Se NPs) by promoting cancer cell autophagy through the regulation of reactive oxygen species (ROS)-mediated c-Jun N-terminal kinase pathway and PI3K/Akt/mTOR pathway.
FIGURE 3
FIGURE 3
Protective effects of selenium nanoparticles (Se NPs) regulated autophagy against H2O2-induced cell dysfunction by regulating mTOR/PINK1-mediated pathway, PERK/eIF2α/ATF4 and AMPK/mTOR/PINK1 signaling pathway.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Mizushima N, Komatsu M. Autophagy: renovation of cells and tissues. Cell. (2011) 147:728–41. 10.1016/j.cell.2011.10.026 - DOI - PubMed
    1. Mizushima N. Autophagy: process and function. Genes Dev. (2007) 21:2861–73. 10.1101/gad.1599207 - DOI - PubMed
    1. Glick D, Barth S, Macleod KF. Autophagy: cellular and molecular mechanisms. J Pathol. (2010) 221:3–12. 10.1002/path.2697 - DOI - PMC - PubMed
    1. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. (2008) 132:27–42. 10.1016/j.cell.2007.12.018 - DOI - PMC - PubMed
    1. Ichimiya T, Yamakawa T, Hirano T, Yokoyama Y, Hayashi Y, Hirayama D, et al. Autophagy and autophagy-related diseases: a review. Int J Mol Sci. (2020) 21:8974. 10.3390/ijms21238974 - DOI - PMC - PubMed

LinkOut - more resources