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. 2023 Jan 26:14:138-145.
doi: 10.1016/j.ibneur.2023.01.007. eCollection 2023 Jun.

Outcomes of single brain metastasis treated with gamma knife stereotaxic radiosurgery(GKSR). Our experience on 103 cases

Nourou Dine Adeniran Bankole  1   2 , Adyl Melhaoui  1   2 , Yasser Arkha  1   2 , Afaf Semmar  1   2 , Khalid Bouyakhlef  1   2 , Mohamed Jiddane  1   2 , Abdeslam El Khamlichi  1   2
Affiliations

Outcomes of single brain metastasis treated with gamma knife stereotaxic radiosurgery(GKSR). Our experience on 103 cases

Nourou Dine Adeniran Bankole et al. IBRO Neurosci Rep. .

Abstract

Background: Brain metastases (BM) occur in the natural course of malignant tumors in 18-40% of cases. Their management has changed considerably over the past decade thanks to the advent of Gamma knife Stereotactic Radiosurgery (GKSR).

Objective: We report our experience on Single Brain metastasis treated with (GKSR).

Methods: Patients treated by Gamma Knife stereotaxic radiosurgery (GKSR) in our institution between 2009 and 2021 for Single BM were recorded retrospectively.

Results: A total of 103 patients (n = 52; 50.5% females) were included, with a mean age of 56.33 ± 11.33. Breast (n = 39, 37.9%) and lung (n = 36, 35%) were the common original location for the primary tumors. GKSR alone without prior surgery, radiotherapy, or chemotherapy was achieved in 81.5% (n = 84). Thirteen patients (15.1%) progressed in BM volume while finding the appearance of de novo BM in 5 (5.8%) patients. The median percentage of tumor control after radiosurgery treatment was 70% (IQR: 65-78) and only 26.2% (n = 27) of patients had > 80% tumor control and stability over the median follow-up time of 5 (95% CI, 4-6) months. We found only two cases of radionecrosis (1.9%). The median survival time was 5.21 (IQR, 3-8) months. Retreatment, recursive partitioning analysis (RPA) class, and tumor stability influenced the overall survival of BM respectively (Hazard Ratio adjust (HRa)= 5.610,p = 0.045; HRa= 6.133,p = 0.031; HRa= 22.463, p = 0.036).

Conclusion: Stereotaxic Radiosurgery provides good results in terms of Overall survival with fewer neurocognitive disorders.RPA class and tumor control (stability) influenced the overall survival of single BM.

Keywords: BM, Brain metastasis; Brain metastasis; Cancer; GKSR, Gamma Knife stereotactic radiosurgery; Gamma knife; HR, Hazard Ratio; HRa, Hazard Ratio adjust; RPA, recursive partitioning analysis; SRS, stereotactic radiosurgery; Stereotaxic Radiosurgery; WBRT, whole brain radiotherapy.

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Figures

Fig. 1
Fig. 1
Primary tumor location in the overall population.
Fig. 2
Fig. 2
Location of Brain metastasis according to their original location.
Fig. 3
Fig. 3
Overall Free Survival progression Kaplan Meir after Stereotactic Radiosurgery for Brain metastasis.
Fig. 4
Fig. 4
Survival Time according to the recursive partitioning analysis(RPA) class primarily controlled, progression, and Brain metastasis retreatment.
See this image and copyright information in PMC

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References

    1. Nayak L., Lee E.Q., Wen P.Y. Epidemiology of brain metastases. Curr. Oncol. Rep. févr. 2012;14(1):48–54. - PubMed
    1. Trifiletti D.M., Hill C., Cohen-Inbar O., Xu Z., Sheehan J.P. Stereotactic radiosurgery for small brain metastases and implications regarding management with systemic therapy alone. J. Neurooncol. 2017;134(2):289–296. 1 sept. - PubMed
    1. Patel A., Mohammadi H., Dong T., Shiue K.R.Y., Frye D., Le Y., et al. Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience. CNS Oncol. janv. 2018;7(1):15–23. - PMC - PubMed
    1. Kocher M., Wittig A., Piroth M.D., Treuer H., Seegenschmiedt H., Ruge M., et al. Stereotactic radiosurgery for treatment of brain metastases. Strahl. Onkol. 2014;190(6):521–532. 1 juin. - PubMed
    1. Mehta M.P., Tsao M.N., Whelan T.J., Morris D.E., Hayman J.A., Flickinger J.C., et al. The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases. Int J. Radiat. Oncol. Biol. Phys. 2005;63(1):37–46. 1 sept. - PubMed

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