COVID-19 vaccination and immune thrombocytopenia: Cause for vigilance, but not panic

Hanny Al-Samkari^{1

2}

Affiliations

Hanny Al-Samkari. Res Pract Thromb Haemost. 2023 Jan.

. 2023 Jan;7(1):100039.

doi: 10.1016/j.rpth.2023.100039. Epub 2023 Feb 15.

Hanny Al-Samkari^{1

2}

No abstract available

Figures

Robotic Splenectomy as a Salvage Therapy Post Failed Splenic Embolization in Chronic Immune Thrombocytopenic Purpura Due to the COVID-19 Vaccine.
Canfield DE, Pizano A, Joseph T. Canfield DE, et al. Cureus. 2025 Mar 31;17(3):e81536. doi: 10.7759/cureus.81536. eCollection 2025 Mar. Cureus. 2025. PMID: 40314051 Free PMC article.
Immune Thrombocytopenia After COVID-19 Vaccine Requiring Splenectomy: A Case Report and Review of the Literature.
Alkhelaiwy L, Fatani JA, Alhamoud I, Chaballout A. Alkhelaiwy L, et al. Cureus. 2024 Feb 10;16(2):e53955. doi: 10.7759/cureus.53955. eCollection 2024 Feb. Cureus. 2024. PMID: 38469016 Free PMC article.
Adverse Events Following COVID-19 Vaccination in Adolescents: Insights From Pharmacovigilance Study of VigiBase.
Kim DH, Kim JH, Oh IS, Choe YJ, Choe SA, Shin JY. Kim DH, et al. J Korean Med Sci. 2024 Mar 4;39(8):e76. doi: 10.3346/jkms.2024.39.e76. J Korean Med Sci. 2024. PMID: 38442719 Free PMC article.
Safety and Immunogenicity of a Modified Self-Amplifying Ribonucleic Acid (saRNA) Vaccine Encoding SARS-CoV-2 Spike Glycoprotein in SARS-CoV-2 Seronegative and Seropositive Ugandan Individuals.
Kitonsa J, Serwanga J, Cheeseman HM, Abaasa A, Lunkuse JF, Ruzagira E, Kato L, Nambaziira F, Oluka GK, Gombe B, Jackson S, Ssebwana JK, McFarlane LR, Joseph S, Pierce BF, Shattock RJ, Kaleebu P. Kitonsa J, et al. Vaccines (Basel). 2025 May 23;13(6):553. doi: 10.3390/vaccines13060553. Vaccines (Basel). 2025. PMID: 40573884 Free PMC article.

1. Young-Ill Choi P., Hsu D., Tran H.A., Tan C.W., Enjeti A., Yee Chen V.M., et al. Immune thrombocytopenia and COVID-19 vaccination: outcomes and comparisons to pre-pandemic patients. Res Pract Thromb Haemost. 2023;7:100009. doi: 10.1016/j.rpth.2022.100009. - DOI - PMC - PubMed
1. Grimaldi-Bensouda L., Michel M., Aubrun E., Leighton P., Viallard J.F., Adoue D., et al. A case-control study to assess the risk of immune thrombocytopenia associated with vaccines. Blood. 2012;120:4938–4944. - PubMed
1. Garbe E., Andersohn F., Bronder E., Salama A., Klimpel A., Thomae M., et al. Drug-induced immune thrombocytopaenia: results from the Berlin Case-Control Surveillance Study. Eur J Clin Pharmacol. 2012;68:821–832. - PubMed
1. Lafaurie M., Lapeyre-Mestre M., Sailler L., Sommet A., Moulis G. Risk of immune thrombocytopenia after influenza vaccine. JAMA Intern Med. 2022;182:444–445. - PMC - PubMed
1. Black C., Kaye J.A., Jick H. MMR vaccine and idiopathic thrombocytopaenic purpura. Br J Clin Pharmacol. 2003;55:107–111. - PMC - PubMed