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. 2023 Feb 20:56:e0333.
doi: 10.1590/0037-8682-0333-2022. eCollection 2023.

Increase in mucormycosis hospitalizations in southeastern Brazil during the COVID-19 pandemic: a 2010-2021 time series

Ivan Lira Dos Santos  1 , Carolina Specian Sartori  2 , André Giglio Bueno  1   2 , Elisa Teixeira Mendes  1   2   3
Affiliations

Increase in mucormycosis hospitalizations in southeastern Brazil during the COVID-19 pandemic: a 2010-2021 time series

Ivan Lira Dos Santos et al. Rev Soc Bras Med Trop. .

Abstract

Background: Mucormycosis is a severe invasive fungal disease. During the coronavirus disease 2019 (COVID-19) pandemic, outbreaks have been reported worldwide, but epidemiological studies are still scarce in Brazil.

Methods: We conducted a time-series cohort hospitalization study (2010-2021) in southeastern Brazil.

Results: There were 311 cases (85 during the pandemic), with significant (P < 0.05) involvement of patients older than 40 years (84%), white patients (78%), rhinocerebral site (63%), and São Paulo State residents (84%).

Conclusions: Mucormycosis hospitalizations were highly prevalent. Further studies are needed to assess the burden of COVID-19 on mucormycosis in Brazil.

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Conflict of interest statement

Conflicts of Interest: The authors declare no conflict of interest.

Figures

FIGURE 1:
FIGURE 1:. Time series of mucormycosis hospitalizations in southeastern Brazil (2010-2021). Source: Sistema de Informações Hospitalares (SIH) [Brazilian Hospital Information System].
FIGURE 2:
FIGURE 2:. Map of mucormycosis hospitalizations according to the municipality of residence in southeastern Brazil (2010-2021). Source: Sistema de Informações Hospitalares (SIH) [Brazilian Hospital Information System].
See this image and copyright information in PMC

References

    1. Cornely OA, Alastruey-Izquierdo A, Arenz D, Chen SCA, Dannaoui E, Hochhegger B, et al. Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium. Lancet Infect Dis. 2019;19(12):e405-21. doi: 10.1016/S1473-3099(19)30312-3. - DOI - PMC - PubMed
    1. Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, et al. The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports. Clin Microbiol Infect. 2019;25(1):26–34. doi: 10.1016/j.cmi.2018.07.011. - DOI - PubMed
    1. Prakash H, Chakrabarti A. Epidemiology of Mucormycosis in India. Microorganisms. 2021;9(3):523–523. doi: 10.3390/microorganisms9030523. - DOI - PMC - PubMed
    1. Hoenigl M, Seidel D, Carvalho A, Rudramurthy SM, Arastehfar A, Gangneux J-P, et al. The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries. The Lancet Microbe. 2022;3(7):e543-52. doi: 10.1016/S2666-5247(21)00237-8. - DOI - PMC - PubMed
    1. Singh AK, Singh R, Joshi SR, Misra A. Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India. Diabetes Metab Syndr Clin Res Rev. 2021;15(4):102146–102146. doi: 10.1016/j.dsx.2021.05.019. - DOI - PMC - PubMed