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Editorial
. 2023 Feb 1;4(2):128-130.
doi: 10.34067/KID.0000000000000065.

Serologic Studies in Membranous Nephropathy: Novel Strategies and Strengthened Associations

Tiffany N Caza  1 , Christopher P Larsen
Affiliations
Editorial

Serologic Studies in Membranous Nephropathy: Novel Strategies and Strengthened Associations

Tiffany N Caza et al. Kidney360. .
No abstract available

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Figures

Figure 1
Figure 1
Characteristics of serologic testing for THSD7A and PLA2R antibodies in membranous nephropathy. THSD7A and PLA2R antibodies are identified before disease activity and correlate with the degree of proteinuria. Antibody titers fall in response to immunosuppressive therapy and rise before a clinical disease flare, providing usefulness in guiding treatment. Autoantibodies are identified in patients with MN driven by “secondary” disease triggers, where they may serve as a biomarker for both diseases (such as autoimmunity or malignancy). Serologic testing needs to be reliable with high sensitivity and specificity for use in clinical practice, as seen with the measurement of both anti-THSD7A and anti-PLA2R antibodies. MN, membranous nephropathy; PLA2R, phospholipase A2 receptor; THSD7A, thrombospondin type-1 domain-containing 7A.
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References

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