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Editorial
. 2023 Feb 1;4(2):131-133.
doi: 10.34067/KID.0000000000000058.

How Does Aldosterone Work?

Lawrence G Palmer  1   2
Affiliations
Editorial

How Does Aldosterone Work?

Lawrence G Palmer. Kidney360. .
No abstract available

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Figures

Figure 1
Figure 1
Proposed actions of aldosterone to stimulate ENaC. Aldosterone (A) binds to and activates MRs that control the transcription of genes for AIPs. These proteins may be ENaC itself (1) or might also accelerate trafficking of the channel to the apical membrane (2), decelerate removal from the membrane (3), or increase the amount of time the channels are in the open state (4). AIP, aldosterone-induced protein.
See this image and copyright information in PMC

Comment on

References

    1. Edelman IS. Candidate mediators in the action of aldosterone on Na+ transport. In: Hoffman JF, editor. Membrane Transport Processes. Raven Press; 1978:125-140.
    1. Sharp GW, Leaf A. Mechanism of action of aldosterone. Physiol Rev. 1966;46(4):593-633. doi:10.1152/physrev.1966.46.4.593 - DOI - PubMed
    1. Loughlin S Costello HM Roe AJ, et al. . Mapping the transcriptome underpinning acute corticosteroid action within the cortical collecting duct. Kidney360. 2023;4(1):226-240. doi:10.34067/KID.0003582022 - DOI - PMC - PubMed
    1. Gaeggeler HP Gonzalez-Rodriguez E Jaeger NF, et al. . Mineralocorticoid versus glucocorticoid receptor occupancy mediating aldosterone-stimulated sodium transport in a novel renal cell line. J Am Soc Nephrol. 2005;16(4):878-891. doi:10.1681/ASN.2004121110 - DOI - PubMed
    1. Asher C, Wald H, Rossier BC, Garty H. Aldosterone-induced increase in the abundance of Na+ channel subunits. Am J Physiol. 1996;271(2):C605-C611. doi:10.1152/ajpcell.1996.271.2.c605 - DOI - PubMed

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