Treatment of locally advanced rectal cancer and synchronous liver metastases: multicentre comparison of two treatment strategies

Collaborators, Affiliations

Dutch Stage IV Rectal Cancer Group:
G L Beets, A G J Aalbers, T J M Ruers, C B H A Kobus, S V Siemons, C Grootscholten, L G H Dewit, J G van den Berg, K P de Jong, G A P Hospers, A Karrenbeld, E D Geijsen, C J A Punt, E Gootjes, M P W Intven, J M L Roodhart, F Holman, E Kapiteijn, J Melenhorst, J S Cnossen, G J M Creemers

¹ Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
² Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³ Department of Surgery, University of Groningen, Groningen, the Netherlands.
⁴ Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.
⁵ Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.
⁶ Department of Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands.
⁷ Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands.
⁸ Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Maastricht, the Netherlands.
⁹ Department of Surgery, Amsterdam UMC, Cancer Centre Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

Multicenter Study

Jan M van Rees et al. Br J Surg. 2023.

. 2023 Aug 11;110(9):1049-1052.

doi: 10.1093/bjs/znad013.

Dutch Stage IV Rectal Cancer Group:
G L Beets, A G J Aalbers, T J M Ruers, C B H A Kobus, S V Siemons, C Grootscholten, L G H Dewit, J G van den Berg, K P de Jong, G A P Hospers, A Karrenbeld, E D Geijsen, C J A Punt, E Gootjes, M P W Intven, J M L Roodhart, F Holman, E Kapiteijn, J Melenhorst, J S Cnossen, G J M Creemers

¹ Department of Surgical Oncology, Erasmus MC Cancer Institute, Rotterdam, the Netherlands.
² Department of Surgical Oncology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
³ Department of Surgery, University of Groningen, Groningen, the Netherlands.
⁴ Department of Surgery, Catharina Hospital, Eindhoven, the Netherlands.
⁵ Department of Surgery, Radboud University Medical Centre, Nijmegen, the Netherlands.
⁶ Department of Surgery, University Medical Centre Utrecht, Utrecht, the Netherlands.
⁷ Department of Radiation Oncology, Leiden University Medical Centre, Leiden, the Netherlands.
⁸ Department of Radiation Oncology (Maastro), GROW School for Oncology, Maastricht University Medical Centre+, Maastricht, the Netherlands.
⁹ Department of Surgery, Amsterdam UMC, Cancer Centre Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.

No abstract available

Figures

1. Petrelli F, Trevisan F, Cabiddu M, Sgroi G, Bruschieri L, Rausa Eet al. . Total neoadjuvant therapy in rectal cancer: a systematic review and meta-analysis of treatment outcomes. Ann Surg 2020;271:440–448 - PubMed
1. Kapiteijn E, Marijnen CAM, Nagtegaal ID, Putter H, Steup WH, Wiggers Tet al. . Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 2001;345:638–646 - PubMed
1. Bosset JF, Collette L, Calais G, Mineur L, Maingon P, Radosevic-Jelic Let al. . Chemotherapy with preoperative radiotherapy in rectal cancer. N Engl J Med 2006;355:1114–1123 - PubMed
1. Gerard JP, Conroy T, Bonnetain F, Bouche O, Chapet O, Closon-Dejardin MTet al. . Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3–4 rectal cancers: results of FFCD 9203. J Clin Oncol 2006;24:4620–4625 - PubMed
1. Pfeiffer P, Gruenberger T, Glynne-Jones R. Synchronous liver metastases in patients with rectal cancer: can we establish which treatment first? Ther Adv Med Oncol 2018;10:1758835918787993 - PMC - PubMed