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. 2023 Feb 7;9(2):e13509.
doi: 10.1016/j.heliyon.2023.e13509. eCollection 2023 Feb.

Global historical retrospect and future prospects on biomarkers of heart failure: A bibliometric analysis and science mapping

Xin Dong  1   2 , Yafei Xie  2   3   4 , Jianguo Xu  2   5 , Yu Qin  5 , Qingyong Zheng  6 , Rui Hu  7 , Xin Zhang  2   8 , Wenxin Wang  2   8 , Jinhui Tian  4   5 , Kang Yi  2   9
Affiliations

Global historical retrospect and future prospects on biomarkers of heart failure: A bibliometric analysis and science mapping

Xin Dong et al. Heliyon. .

Abstract

Introduction: Heart failure is a rapidly growing public health problem and has become a major cause of hospitalization in middle-aged and older adults. Biomarkers are clinically important in managing heart failure and have attracted more attention from researchers in recent years. This study aimed to evaluate the global research of heart failure biomarkers by bibliometrics and to identify the hot spots and perspectives for further advancement.

Methods: Selection of relevant documents was from the Web of Science Core Collection. Microsoft Excel, VOSviewer, SciMA, and CiteSpace software were used for bibliometric analysis.

Results: As of October 29, 2021, 5,978 documents for heart failure biomarkers have been identified from 1989 to 2021. European Journal of Heart Failure and Circulation respectively ranked first in terms of the number of publications and the number of co-citations. A total of 5,698 institutions from 90 countries participated in these publications, with the USA leading with 2,045 documents. The most productive institution was Harvard University. Januzzi, J.L. and Maisel, A.S. were the most productive and most cited authors respectively. Natriuretic peptide, copeptin, valsartan, ferric carboxymaltose, empagliflozin, preserved ejection fraction, myocardial fibrosis, and heart transplantation were hot themes.

Conclusions: Extensive national and inter-institutional collaboration should be enhanced to bridge the gap between developed and less developed countries in heart failure biomarkers research. The research in this field seems to have reached a relatively mature stage, with a decrease in research fervor in recent years. The study of the natriuretic peptide family still has high centrality, with advances in the study of expression products and inflammatory markers. Cardiac fibrosis, cardiac remodeling, and therapies regarding heart failure have become hot spots.

Keywords: Bibliometric analysis; Biomarker; Citation analysis; Heart failure; Science mapping.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Annual distribution of publications and growth forecast for heart failure biomarkers.
Fig. 2
Fig. 2
Density map of co-cited journals for heart failure biomarkers.
Fig. 3
Fig. 3
Dual-map overlay of journals for heart failure biomarkers.
Fig. 4
Fig. 4
Network map of keywords for heart failure biomarkers.
Fig. 5
Fig. 5
A Overlapping map of keywords for heart failure biomarkers. B Strategic diagrams for heart failure biomarkers.
Fig. 6
Fig. 6
Thematic evolution map for heart failure biomarkers.
See this image and copyright information in PMC

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References

    1. Baman J.R., Ahmad F.S. Heart failure. JAMA. 2020;324:1015. doi: 10.1001/jama.2020.13310. - DOI - PubMed
    1. Stefil M., Manzano L., Montero-PeRez-Barquero M., Coats A.J.S., Flather M. New horizons in management of heart failure in older patients. Age Ageing. 2019;49:16–19. doi: 10.1093/ageing/afz122. - DOI - PubMed
    1. Writing Committee M., Yancy C.W., Jessup M., Bozkurt B., Butler J., Casey D.E., Jr., Drazner M.H., Fonarow G.C., Geraci S.A., Horwich T., et al. 2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2013;128:e240–e327. doi: 10.1161/CIR.0b013e31829e8776. - DOI - PubMed
    1. Cook C., Cole G., Asaria P., Jabbour R., Francis D.P. The annual global economic burden of heart failure. Int. J. Cardiol. 2014;171:368–376. doi: 10.1016/j.ijcard.2013.12.028. - DOI - PubMed
    1. Heidenreich P.A., Albert N.M., Allen L.A., Bluemke D.A., Butler J., Fonarow G.C., Ikonomidis J.S., Khavjou O., Konstam M.A., Maddox T.M., et al. Forecasting the impact of heart failure in the United States: a policy statement from the American Heart Association. Circ. Heart Fail. 2013;6:606–619. doi: 10.1161/HHF.0b013e318291329a. - DOI - PMC - PubMed