Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023;21(4):777-786.
doi: 10.2174/1570159X21666230220102605.

Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Pooja Mittal  1 , Rajat Goyal  2 , Ramit Kapoor  3 , Chunpeng Wan  4 , Rupesh K Gautam  5
Affiliations
Review

Natural Products-based Drugs: Potential Drug Targets Against Neurological Degeneration

Pooja Mittal et al. Curr Neuropharmacol. 2023.

Abstract

Phytochemicals or natural products have been studied extensively for their potential in the treatment of neurodegenerative diseases (NDs) like Parkinson's disease, Alzheimer's disease, etc. The neuronal structure loss and progressive dysfunction are the main characteristics of these diseases. In spite of impressive and thorough knowledge of neurodegenerative molecular pathways, little advancement has been found in the treatment of the same. Moreover, it was proved that natural products can be used efficiently in the treatment of NDs while certain issues regarding the patient's safety and clinical data are still existing. As ND is a bunch of diseases and it will start the myriad of pathological processes, active targeting of the molecular pathway behind ND will be the most efficient strategy to treat all ND-related diseases. The targeting pathway must prevent cell death and should restore the damaged neurons. In the treatment of ND and related diseases, natural products are playing the role of neuroprotective agents. This review will target the therapeutic potential of various phytochemicals which shows neuroprotective action.

Keywords: Alzheimer’s disease; Neurodegeneration; Parkinson’s disease; neuroprotective action; phytochemicals; targeting.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest, financial or otherwise.

Figures

Fig. (1)
Fig. (1)
Therapeutic drug targets and their mechanisms associated with neurodegeneration.
Fig. (2)
Fig. (2)
Mechanism of Neurodegeneration and the role of natural products as neuroprotective.
See this image and copyright information in PMC

References

    1. Abdel-Salam O.M., Sleem A.A., Youness E.R., Yassen N.N., Shaffie N., El-Toumy S.A. Capsicum protects against rotenone-induced toxicity in mice brain via reduced oxidative stress and 5-lipoxygenase activation. J. Pharm. Pharmacogn. Res. 2018;2(3):60–77.
    1. Butterfield D.A. Perspectives on oxidative stress in Alzheimer’s disease and predictions of future research emphases. J. Alzheimers Dis. 2018;64(s1):S469–S479. doi: 10.3233/JAD-179912. - DOI - PubMed
    1. Jiang T., Sun Q., Chen S. Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease. Prog. Neurobiol. 2016;147:1–19. doi: 10.1016/j.pneurobio.2016.07.005. - DOI - PubMed
    2. Paül. Valerià. “Hopes for the countryside’s future. An analysis of two endogenous development experiences in south-eastern galicia. J. Urban Region. Analysis. 2023;5(2):169–192.
    1. da Costa I.M., de Moura Freire M.A., de Paiva Cavalcanti J.R.L., de Araújo D.P., Norrara B., Moreira Rosa I.M.M., de Azevedo E.P., do Rego A.C.M., Filho I.A., Guzen F.P. Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer’s disease: a systematic review. Curr. Neuropharmacol. 2019;17(5):406–421. doi: 10.2174/0929867325666180117112610. - DOI - PMC - PubMed
    1. Reddy P.H., Manczak M., Yin X., Grady M.C., Mitchell A., Kandimalla R., Kuruva C.S. Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer’s disease. J. Investig. Med. 2016;64(8):1220–1234. doi: 10.1136/jim-2016-000240. - DOI - PMC - PubMed

MeSH terms